Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   GFB63_RS05385 Genome accession   NZ_CP045596
Coordinates   1040169..1040909 (+) Length   246 a.a.
NCBI ID   WP_193838172.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain TK-P3A     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1035169..1045909
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GFB63_RS05360 (GFB63_05510) - 1035462..1036358 (+) 897 WP_193838435.1 restriction endonuclease -
  GFB63_RS05365 (GFB63_05515) - 1036699..1037061 (+) 363 WP_039671040.1 SAG1252 family conjugative relaxosome accessory protein -
  GFB63_RS05370 (GFB63_05520) - 1037064..1037429 (+) 366 WP_039671039.1 plasmid mobilization protein -
  GFB63_RS05375 (GFB63_05525) - 1037416..1039299 (+) 1884 WP_193838171.1 SAG1250 family conjugative relaxase -
  GFB63_RS05380 (GFB63_05535) - 1039826..1040167 (+) 342 WP_024404826.1 LytTR family DNA-binding domain-containing protein -
  GFB63_RS05385 (GFB63_05540) comE/blpR 1040169..1040909 (+) 741 WP_193838172.1 response regulator transcription factor Regulator
  GFB63_RS05390 (GFB63_05545) - 1040920..1042260 (+) 1341 WP_193838173.1 sensor histidine kinase -
  GFB63_RS05395 (GFB63_05550) - 1042308..1042463 (-) 156 WP_096811960.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  GFB63_RS05400 (GFB63_05555) comB 1042562..1043923 (-) 1362 WP_193838174.1 bacteriocin secretion accessory protein Regulator

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28836.05 Da        Isoelectric Point: 7.2201

>NTDB_id=345228 GFB63_RS05385 WP_193838172.1 1040169..1040909(+) (comE/blpR) [Streptococcus thermophilus strain TK-P3A]
MNIFVIEDDFMQQARIEKIITKLLEKHNIVPKKFEISGKPHQLLQAIEEKGVHQLFFLDIEIKEDELKGLQVAKQIREID
PYASIVFVTTHSEFMSLSFRYQVSALDYIDKELGVTEFESRIEAALLHTHNKDNSAVSDDSFYFKSKYAQVQYPFNEVYY
IETSPRPHRVILYTKTDRMEFTASLSDILKQDKRLVQCHRSFAINPRNVVKVDRNEKQIYFPNGATCFISRQKLESALAV
IDRLHR

Nucleotide


Download         Length: 741 bp        

>NTDB_id=345228 GFB63_RS05385 WP_193838172.1 1040169..1040909(+) (comE/blpR) [Streptococcus thermophilus strain TK-P3A]
ATGAATATCTTTGTAATAGAAGATGATTTTATGCAACAAGCGAGAATTGAGAAGATTATTACTAAGCTGTTAGAAAAGCA
CAACATCGTTCCGAAAAAATTTGAAATTTCAGGAAAACCTCATCAGCTACTTCAAGCAATAGAAGAAAAAGGAGTACATC
AGCTCTTCTTTTTAGATATTGAGATTAAGGAAGACGAACTAAAAGGACTTCAAGTCGCTAAACAAATTAGAGAGATTGAC
CCTTATGCTAGTATTGTTTTTGTGACAACACACTCCGAGTTTATGTCCTTATCTTTCAGGTACCAGGTATCTGCCTTGGA
CTATATTGACAAAGAGCTTGGAGTTACCGAATTTGAATCGCGAATAGAAGCAGCTTTACTTCATACTCACAATAAGGACA
ATAGCGCCGTATCGGATGATTCATTCTATTTTAAGTCCAAATATGCTCAAGTACAATACCCATTCAATGAAGTGTACTAC
ATCGAGACTTCTCCCCGCCCTCATCGTGTTATCCTTTATACCAAGACAGACCGAATGGAGTTCACAGCAAGTTTGTCAGA
CATTTTGAAACAAGATAAACGACTTGTACAATGTCATCGTTCGTTTGCAATCAATCCGAGGAATGTTGTTAAAGTGGATA
GAAATGAAAAACAGATCTACTTTCCTAATGGAGCCACCTGTTTTATTTCAAGGCAAAAGCTAGAATCAGCTTTAGCTGTT
ATTGATAGACTGCATAGATAA

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(151-236)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.306

98.374

0.524
  comE/comE1 Streptococcus equinus JB1

41.423

97.154

0.402
  comE/comE2 Streptococcus equinus JB1

36.475

99.187

0.362