Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ETT46_RS01860 Genome accession   NZ_CP035453
Coordinates   327172..327858 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm100     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 322172..332858
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT46_RS01835 (ETT46_01835) ktrB 322315..323691 (-) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -
  ETT46_RS01840 (ETT46_01840) rsmG 323775..324488 (-) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ETT46_RS01845 (ETT46_01845) - 324638..325195 (+) 558 WP_002985956.1 LemA family protein -
  ETT46_RS01850 (ETT46_01850) htpX 325242..326138 (+) 897 WP_047235158.1 zinc metalloprotease HtpX -
  ETT46_RS01855 (ETT46_01855) - 326372..326905 (+) 534 WP_011054200.1 DUF177 domain-containing protein -
  ETT46_RS01860 (ETT46_01860) covR 327172..327858 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  ETT46_RS01865 (ETT46_01865) covS 327864..329366 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  ETT46_RS01870 (ETT46_01870) nrdR 329581..330075 (+) 495 WP_031488561.1 transcriptional regulator NrdR -
  ETT46_RS01875 (ETT46_01875) - 330059..331234 (+) 1176 WP_031488562.1 replication initiation and membrane attachment family protein -
  ETT46_RS01880 (ETT46_01880) dnaI 331235..332137 (+) 903 WP_038432808.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=342396 ETT46_RS01860 WP_002991052.1 327172..327858(+) (covR) [Streptococcus pyogenes strain emm100]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=342396 ETT46_RS01860 WP_002991052.1 327172..327858(+) (covR) [Streptococcus pyogenes strain emm100]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment