Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ETT61_RS02055 Genome accession   NZ_CP035438
Coordinates   370268..370954 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm22.8     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 365268..375954
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT61_RS02030 (ETT61_02030) ktrB 365410..366786 (-) 1377 WP_033887684.1 potassium uptake transporter channel subunit KtrB -
  ETT61_RS02035 (ETT61_02035) rsmG 366871..367584 (-) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ETT61_RS02040 (ETT61_02040) - 367734..368291 (+) 558 WP_002985956.1 LemA family protein -
  ETT61_RS02045 (ETT61_02045) htpX 368338..369234 (+) 897 WP_136019974.1 zinc metalloprotease HtpX -
  ETT61_RS02050 (ETT61_02050) - 369468..370001 (+) 534 WP_032464180.1 DUF177 domain-containing protein -
  ETT61_RS02055 (ETT61_02055) covR 370268..370954 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  ETT61_RS02060 (ETT61_02060) covS 370960..372462 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  ETT61_RS02065 (ETT61_02065) nrdR 372677..373171 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  ETT61_RS02070 (ETT61_02070) - 373155..374330 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  ETT61_RS02075 (ETT61_02075) dnaI 374331..375233 (+) 903 WP_129322224.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=341580 ETT61_RS02055 WP_002991052.1 370268..370954(+) (covR) [Streptococcus pyogenes strain emm22.8]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=341580 ETT61_RS02055 WP_002991052.1 370268..370954(+) (covR) [Streptococcus pyogenes strain emm22.8]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATCCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment