Detailed information NTG0341350

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT65_RS00330
• Genome accession: NZ_CP035434
• Coordinates: 53054..53965 (+)
• Length: 303 a.a.
• NCBI ID: WP_023611326.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm75.1
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48054..58965

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT65_RS00310 (ETT65_00310)	purE	48350..48841 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT65_RS00315 (ETT65_00315)	purK	48828..49901 (+)	1074	WP_168436230.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT65_RS00320 (ETT65_00320)	-	49922..51262 (+)	1341	WP_002987721.1	hypothetical protein	-
ETT65_RS00325 (ETT65_00325)	purB	51631..52923 (+)	1293	WP_136098009.1	adenylosuccinate lyase	-
ETT65_RS00330 (ETT65_00330)	comR	53054..53965 (+)	912	WP_023611326.1	transcriptional regulator Rgg4/ComR	Regulator
ETT65_RS09800	comS	54049..54144 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
ETT65_RS00335 (ETT65_00335)	ruvB	54191..55189 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ETT65_RS00340 (ETT65_00340)	-	55327..55764 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ETT65_RS00345 (ETT65_00345)	-	55787..56188 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT65_RS00350 (ETT65_00350)	-	56185..57960 (+)	1776	WP_023612103.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35685.21 Da
• Isoelectric Point: 4.5164

>NTDB_id=341350 ETT65_RS00330 WP_023611326.1 53054..53965(+) (comR) [Streptococcus pyogenes strain emm75.1]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSGQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=341350 ETT65_RS00330 WP_023611326.1 53054..53965(+) (comR) [Streptococcus pyogenes strain emm75.1]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGGACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462