Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ETT66_RS07725 Genome accession   NZ_CP035433
Coordinates   1531238..1531924 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm65     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1526238..1536924
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT66_RS07700 (ETT66_07695) - 1526600..1527775 (-) 1176 WP_009880401.1 replication initiation and membrane attachment family protein -
  ETT66_RS07705 (ETT66_07700) nrdR 1527759..1528253 (-) 495 WP_011184190.1 transcriptional regulator NrdR -
  ETT66_RS07715 (ETT66_07710) - 1528427..1529495 (-) 1069 Protein_1427 ISAs1 family transposase -
  ETT66_RS07720 (ETT66_07715) covS 1529729..1531232 (-) 1504 Protein_1428 two-component system sensor histidine kinase CovS -
  ETT66_RS07725 (ETT66_07720) covR 1531238..1531924 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  ETT66_RS07730 (ETT66_07725) - 1532191..1532724 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  ETT66_RS07735 (ETT66_07730) htpX 1532958..1533854 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  ETT66_RS07740 (ETT66_07735) - 1533901..1534458 (-) 558 WP_136110238.1 LemA family protein -
  ETT66_RS07745 (ETT66_07740) rsmG 1534609..1535322 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ETT66_RS07750 (ETT66_07745) ktrB 1535407..1536783 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=341341 ETT66_RS07725 WP_002991052.1 1531238..1531924(-) (covR) [Streptococcus pyogenes strain emm65]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=341341 ETT66_RS07725 WP_002991052.1 1531238..1531924(-) (covR) [Streptococcus pyogenes strain emm65]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment