Detailed information NTG0338679

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EQH15_RS02580
• Genome accession: NZ_CP035265
• Coordinates: 500139..500876 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain TVO_1901920
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 495139..505876

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH15_RS02545	-	496069..496308 (-)	240	WP_001813906.1	hypothetical protein	-
EQH15_RS02550 (EQH15_02675)	-	496470..496757 (-)	288	WP_000777760.1	hypothetical protein	-
EQH15_RS02555 (EQH15_02680)	-	496767..497177 (-)	411	WP_001278301.1	HIT family protein	-
EQH15_RS02560 (EQH15_02685)	pptA	497245..497976 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
EQH15_RS02565 (EQH15_02690)	-	497973..499022 (+)	1050	WP_000653752.1	ABC transporter permease	-
EQH15_RS02570 (EQH15_02695)	-	499190..499519 (-)	330	WP_000132572.1	hypothetical protein	-
EQH15_RS02575 (EQH15_02700)	-	499796..500134 (+)	339	WP_000682121.1	LytTR family DNA-binding domain-containing protein	-
EQH15_RS02580 (EQH15_02705)	comE/blpR	500139..500876 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
EQH15_RS02585 (EQH15_02710)	-	500890..502230 (+)	1341	WP_001017622.1	sensor histidine kinase	-
EQH15_RS02590 (EQH15_02715)	blpC	502272..502427 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
EQH15_RS02595 (EQH15_02720)	-	502484..503845 (-)	1362	Protein_512	bacteriocin secretion accessory protein	-
EQH15_RS02600 (EQH15_02725)	comA/nlmT	503856..505532 (-)	1677	WP_306423909.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=338679 EQH15_RS02580 WP_001219126.1 500139..500876(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901920]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=338679 EQH15_RS02580 WP_001219126.1 500139..500876(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901920]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384