Detailed information NTG0338548

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH17_RS08245
• Genome accession: NZ_CP035263
• Coordinates: 1676376..1677035 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain TVO_1901922
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1671376..1682035

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH17_RS08220 (EQH17_08715)	-	1671681..1671998 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH17_RS08225 (EQH17_08720)	-	1672013..1672909 (-)	897	WP_000825669.1	PEP phosphonomutase	-
EQH17_RS08230 (EQH17_08725)	-	1672912..1674174 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
EQH17_RS08235 (EQH17_08730)	-	1674454..1675632 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
EQH17_RS08240 (EQH17_08735)	-	1675908..1676306 (-)	399	WP_000155403.1	N-acetyltransferase	-
EQH17_RS08245 (EQH17_08740)	cclA/cilC	1676376..1677035 (+)	660	WP_000565010.1	A24 family peptidase	Machinery gene
EQH17_RS08250 (EQH17_08745)	-	1677087..1678238 (-)	1152	WP_000481751.1	ImmA/IrrE family metallo-endopeptidase	-
EQH17_RS08255 (EQH17_08750)	-	1678253..1678984 (-)	732	Protein_1656	hypothetical protein	-
EQH17_RS08260 (EQH17_08755)	-	1679204..1679314 (+)	111	Protein_1657	prepilin peptidase	-
EQH17_RS08265 (EQH17_08760)	trpA	1679286..1680062 (-)	777	WP_001126993.1	tryptophan synthase subunit alpha	-
EQH17_RS08270 (EQH17_08765)	trpB	1680055..1681278 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
EQH17_RS08275 (EQH17_08770)	-	1681256..1681855 (-)	600	WP_000169909.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=338548 EQH17_RS08245 WP_000565010.1 1676376..1677035(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901922]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=338548 EQH17_RS08245 WP_000565010.1 1676376..1677035(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901922]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877