Detailed information NTG0338471

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH18_RS08305
• Genome accession: NZ_CP035262
• Coordinates: 1682188..1682847 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565023.1
• Uniprot ID: A0A0I8D2P0
• Organism: Streptococcus pneumoniae strain TVO_1901923
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1677188..1687847

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH18_RS08280 (EQH18_08750)	-	1677493..1677810 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH18_RS08285 (EQH18_08755)	-	1677825..1678721 (-)	897	WP_000825669.1	PEP phosphonomutase	-
EQH18_RS08290 (EQH18_08760)	-	1678724..1679986 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
EQH18_RS08295 (EQH18_08765)	-	1680266..1681444 (+)	1179	WP_000175881.1	ROK family transcriptional regulator	-
EQH18_RS08300 (EQH18_08770)	-	1681672..1682118 (-)	447	WP_000155407.1	GNAT family N-acetyltransferase	-
EQH18_RS08305 (EQH18_08775)	cclA/cilC	1682188..1682847 (+)	660	WP_000565023.1	A24 family peptidase	Machinery gene
EQH18_RS08310 (EQH18_08780)	trpA	1682819..1683595 (-)	777	WP_001127001.1	tryptophan synthase subunit alpha	-
EQH18_RS08315 (EQH18_08785)	trpB	1683588..1684811 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
EQH18_RS08320 (EQH18_08790)	-	1684789..1685388 (-)	600	WP_000169909.1	phosphoribosylanthranilate isomerase	-
EQH18_RS08325 (EQH18_08795)	trpC	1685375..1686142 (-)	768	WP_000076548.1	indole-3-glycerol phosphate synthase TrpC	-
EQH18_RS08330 (EQH18_08800)	trpD	1686139..1687143 (-)	1005	WP_000658684.1	anthranilate phosphoribosyltransferase	-
EQH18_RS08335 (EQH18_08805)	-	1687154..1687720 (-)	567	WP_000601921.1	aminodeoxychorismate/anthranilate synthase component II	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24921.13 Da
• Isoelectric Point: 8.2409

>NTDB_id=338471 EQH18_RS08305 WP_000565023.1 1682188..1682847(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901923]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=338471 EQH18_RS08305 WP_000565023.1 1682188..1682847(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901923]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0I8D2P0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae Rx1	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae D39	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae R6	96.347	100	0.963
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	86.301	100	0.863