Detailed information NTG0338369

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EQH19_RS02625
• Genome accession: NZ_CP035261
• Coordinates: 517737..518474 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219145.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901924
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 512737..523474

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH19_RS02590	-	513775..514014 (-)	240	WP_001812223.1	hypothetical protein	-
EQH19_RS02595 (EQH19_02740)	-	514176..514463 (-)	288	WP_000777760.1	hypothetical protein	-
EQH19_RS02600 (EQH19_02745)	-	514473..514883 (-)	411	WP_001278301.1	HIT family protein	-
EQH19_RS02605 (EQH19_02750)	pptA	514951..515682 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
EQH19_RS02610 (EQH19_02755)	-	515679..516728 (+)	1050	WP_000653753.1	ABC transporter permease	-
EQH19_RS02615 (EQH19_02760)	-	516789..517118 (-)	330	WP_000132568.1	hypothetical protein	-
EQH19_RS02620 (EQH19_02765)	-	517394..517732 (+)	339	WP_000682121.1	LytTR family DNA-binding domain-containing protein	-
EQH19_RS02625 (EQH19_02770)	comE/blpR	517737..518474 (+)	738	WP_001219145.1	response regulator transcription factor	Regulator
EQH19_RS02630 (EQH19_02775)	-	518488..519828 (+)	1341	WP_001017621.1	sensor histidine kinase	-
EQH19_RS02635 (EQH19_02780)	blpC	519870..520025 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
EQH19_RS02640 (EQH19_02785)	-	520082..521461 (-)	1380	Protein_524	bacteriocin secretion accessory protein	-
EQH19_RS02645 (EQH19_02790)	comA/nlmT	521454..523130 (-)	1677	WP_307774231.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28798.90 Da
• Isoelectric Point: 6.0454

>NTDB_id=338369 EQH19_RS02625 WP_001219145.1 517737..518474(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901924]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=338369 EQH19_RS02625 WP_001219145.1 517737..518474(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901924]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363