Detailed information NTG0338316

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH20_RS07820
• Genome accession: NZ_CP035260
• Coordinates: 1565246..1565905 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565001.1
• Uniprot ID: A0A0B7M7B9
• Organism: Streptococcus pneumoniae strain TVO_1901925
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1560246..1570905

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH20_RS07795 (EQH20_08240)	-	1560551..1560868 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH20_RS07800 (EQH20_08245)	-	1560883..1561779 (-)	897	WP_000825667.1	PEP phosphonomutase	-
EQH20_RS07805 (EQH20_08250)	-	1561782..1563044 (-)	1263	WP_000413342.1	PTS sugar transporter subunit IIC	-
EQH20_RS07810 (EQH20_08255)	-	1563324..1564502 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
EQH20_RS07815 (EQH20_08260)	-	1564730..1565176 (-)	447	WP_000155399.1	GNAT family N-acetyltransferase	-
EQH20_RS07820 (EQH20_08265)	cclA/cilC	1565246..1565905 (+)	660	WP_000565001.1	A24 family peptidase	Machinery gene
EQH20_RS07825 (EQH20_08270)	-	1565957..1567108 (-)	1152	WP_000481756.1	XRE family transcriptional regulator	-
EQH20_RS07830 (EQH20_08275)	-	1567123..1567854 (-)	732	WP_000934017.1	hypothetical protein	-
EQH20_RS07835 (EQH20_08280)	-	1568074..1568184 (+)	111	Protein_1564	prepilin peptidase	-
EQH20_RS07840 (EQH20_08285)	trpA	1568156..1568932 (-)	777	WP_001127015.1	tryptophan synthase subunit alpha	-
EQH20_RS07845 (EQH20_08290)	trpB	1568925..1570148 (-)	1224	WP_000331292.1	tryptophan synthase subunit beta	-
EQH20_RS07850 (EQH20_08295)	-	1570126..1570725 (-)	600	WP_000169898.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24820.92 Da
• Isoelectric Point: 7.2761

>NTDB_id=338316 EQH20_RS07820 WP_000565001.1 1565246..1565905(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901925]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=338316 EQH20_RS07820 WP_000565001.1 1565246..1565905(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901925]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTACTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M7B9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	98.174	100	0.982
cclA/cilC	Streptococcus pneumoniae Rx1	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae D39	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae R6	96.804	100	0.968
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872