Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   EQH22_RS08210 Genome accession   NZ_CP035258
Coordinates   1645804..1646463 (+) Length   219 a.a.
NCBI ID   WP_000565011.1    Uniprot ID   A0A2R2HSW7
Organism   Streptococcus pneumoniae strain TVO_1901927     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1640804..1651463
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH22_RS08175 (EQH22_08600) mgaSpn 1641036..1642517 (-) 1482 WP_001205280.1 virulence factor transcriptional regulator MgaSpn -
  EQH22_RS11065 (EQH22_08605) - 1642941..1643153 (+) 213 Protein_1644 GlsB/YeaQ/YmgE family stress response membrane protein -
  EQH22_RS08180 (EQH22_08610) amaP 1643237..1643803 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  EQH22_RS08185 (EQH22_08615) - 1643815..1643985 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  EQH22_RS08190 (EQH22_08620) - 1644024..1644632 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  EQH22_RS08195 (EQH22_08625) - 1644663..1644866 (+) 204 WP_000109957.1 CsbD family protein -
  EQH22_RS08200 (EQH22_08630) - 1644976..1645215 (-) 240 WP_001005784.1 transposase -
  EQH22_RS08205 (EQH22_08635) - 1645288..1645734 (-) 447 WP_000155431.1 GNAT family N-acetyltransferase -
  EQH22_RS08210 (EQH22_08640) cclA/cilC 1645804..1646463 (+) 660 WP_000565011.1 A24 family peptidase Machinery gene
  EQH22_RS08215 (EQH22_08645) trpA 1646435..1647211 (-) 777 WP_001126995.1 tryptophan synthase subunit alpha -
  EQH22_RS08220 (EQH22_08650) trpB 1647204..1648427 (-) 1224 WP_000331298.1 tryptophan synthase subunit beta -
  EQH22_RS08225 (EQH22_08655) - 1648405..1649004 (-) 600 WP_000169872.1 phosphoribosylanthranilate isomerase -
  EQH22_RS08230 (EQH22_08660) trpC 1648991..1649758 (-) 768 WP_000076544.1 indole-3-glycerol phosphate synthase TrpC -
  EQH22_RS08235 (EQH22_08665) trpD 1649755..1650759 (-) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  EQH22_RS08240 (EQH22_08670) - 1650770..1651336 (-) 567 WP_000601930.1 aminodeoxychorismate/anthranilate synthase component II -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24890.04 Da        Isoelectric Point: 7.5762

>NTDB_id=338162 EQH22_RS08210 WP_000565011.1 1645804..1646463(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901927]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=338162 EQH22_RS08210 WP_000565011.1 1645804..1646463(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901927]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2R2HSW7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae D39

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae R6

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae TIGR4

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

86.758

100

0.868

Multiple sequence alignment