Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   EQH26_RS10775 Genome accession   NZ_CP035254
Coordinates   2113802..2115127 (-) Length   441 a.a.
NCBI ID   WP_000364844.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901932     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2108802..2120127
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH26_RS10750 (EQH26_11290) - 2110507..2112089 (-) 1583 Protein_2104 YhgE/Pip family protein -
  EQH26_RS10755 (EQH26_11295) - 2112268..2112810 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  EQH26_RS10770 (EQH26_11310) comE 2113053..2113805 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  EQH26_RS10775 (EQH26_11315) comD/comD2 2113802..2115127 (-) 1326 WP_000364844.1 competence system sensor histidine kinase ComD Regulator
  EQH26_RS10780 (EQH26_11320) comC/comC2 2115148..2115273 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  EQH26_RS10790 (EQH26_11330) rlmH 2115555..2116034 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQH26_RS10795 (EQH26_11335) htrA 2116217..2117398 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  EQH26_RS10800 (EQH26_11340) spo0J 2117456..2118214 (+) 759 WP_000410381.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51417.03 Da        Isoelectric Point: 7.5816

>NTDB_id=337957 EQH26_RS10775 WP_000364844.1 2113802..2115127(-) (comD/comD2) [Streptococcus pneumoniae strain TVO_1901932]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVIFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTITPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=337957 EQH26_RS10775 WP_000364844.1 2113802..2115127(-) (comD/comD2) [Streptococcus pneumoniae strain TVO_1901932]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAATTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATAACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTATAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.773

100

0.998
  comD/comD1 Streptococcus pneumoniae Rx1

96.599

100

0.966
  comD/comD1 Streptococcus pneumoniae D39

96.599

100

0.966
  comD/comD1 Streptococcus pneumoniae R6

96.599

100

0.966
  comD Streptococcus mitis SK321

91.837

100

0.918
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422

Multiple sequence alignment