Detailed information NTG0337956

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH26_RS10770
• Genome accession: NZ_CP035254
• Coordinates: 2113053..2113805 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901932
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2108053..2118805

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH26_RS10750 (EQH26_11290)	-	2110507..2112089 (-)	1583	Protein_2104	YhgE/Pip family protein	-
EQH26_RS10755 (EQH26_11295)	-	2112268..2112810 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH26_RS10770 (EQH26_11310)	comE	2113053..2113805 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH26_RS10775 (EQH26_11315)	comD/comD2	2113802..2115127 (-)	1326	WP_000364844.1	competence system sensor histidine kinase ComD	Regulator
EQH26_RS10780 (EQH26_11320)	comC/comC2	2115148..2115273 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
EQH26_RS10790 (EQH26_11330)	rlmH	2115555..2116034 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH26_RS10795 (EQH26_11335)	htrA	2116217..2117398 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH26_RS10800 (EQH26_11340)	spo0J	2117456..2118214 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337956 EQH26_RS10770 WP_000866065.1 2113053..2113805(-) (comE) [Streptococcus pneumoniae strain TVO_1901932]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337956 EQH26_RS10770 WP_000866065.1 2113053..2113805(-) (comE) [Streptococcus pneumoniae strain TVO_1901932]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408