Detailed information NTG0337841

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH28_RS08490
• Genome accession: NZ_CP035252
• Coordinates: 1691955..1692614 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain TVO_1901934
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1686955..1697614

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH28_RS08465 (EQH28_08980)	-	1687260..1687577 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH28_RS08470 (EQH28_08985)	-	1687592..1688488 (-)	897	WP_000825668.1	PEP phosphonomutase	-
EQH28_RS08475 (EQH28_08990)	-	1688491..1689753 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
EQH28_RS08480 (EQH28_08995)	-	1690033..1691211 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
EQH28_RS08485 (EQH28_09000)	-	1691439..1691885 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH28_RS08490 (EQH28_09005)	cclA/cilC	1691955..1692614 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
EQH28_RS08495 (EQH28_09010)	-	1692666..1693817 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
EQH28_RS08500 (EQH28_09015)	-	1693832..1694563 (-)	732	WP_000934017.1	hypothetical protein	-
EQH28_RS08505 (EQH28_09020)	-	1694789..1694893 (+)	105	Protein_1702	prepilin peptidase	-
EQH28_RS08510 (EQH28_09025)	trpA	1694865..1695641 (-)	777	WP_001126997.1	tryptophan synthase subunit alpha	-
EQH28_RS08515 (EQH28_09030)	trpB	1695634..1696857 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
EQH28_RS08520 (EQH28_09035)	-	1696835..1697434 (-)	600	WP_000169892.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=337841 EQH28_RS08490 WP_000565017.1 1691955..1692614(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901934]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=337841 EQH28_RS08490 WP_000565017.1 1691955..1692614(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901934]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858