Detailed information NTG0337762

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH29_RS08230
• Genome accession: NZ_CP035251
• Coordinates: 1663730..1664389 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain TVO_1901935
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1658730..1669389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH29_RS08205 (EQH29_08725)	-	1659035..1659352 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH29_RS08210 (EQH29_08730)	-	1659367..1660263 (-)	897	WP_000825668.1	PEP phosphonomutase	-
EQH29_RS08215 (EQH29_08735)	-	1660266..1661528 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
EQH29_RS08220 (EQH29_08740)	-	1661808..1662986 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
EQH29_RS08225 (EQH29_08745)	-	1663214..1663660 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH29_RS08230 (EQH29_08750)	cclA/cilC	1663730..1664389 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
EQH29_RS08235 (EQH29_08755)	-	1664441..1665592 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
EQH29_RS08240 (EQH29_08760)	-	1665607..1666338 (-)	732	WP_000934017.1	hypothetical protein	-
EQH29_RS08245 (EQH29_08765)	-	1666564..1666668 (+)	105	Protein_1650	prepilin peptidase	-
EQH29_RS08250 (EQH29_08770)	trpA	1666640..1667416 (-)	777	WP_001126997.1	tryptophan synthase subunit alpha	-
EQH29_RS08255 (EQH29_08775)	trpB	1667409..1668632 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
EQH29_RS08260 (EQH29_08780)	-	1668610..1669209 (-)	600	WP_000169892.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=337762 EQH29_RS08230 WP_000565017.1 1663730..1664389(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901935]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=337762 EQH29_RS08230 WP_000565017.1 1663730..1664389(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901935]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858