Detailed information NTG0337525

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH33_RS08050
• Genome accession: NZ_CP035247
• Coordinates: 1611211..1611870 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain TVO_1901940
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1606211..1616870

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH33_RS08025 (EQH33_08510)	-	1606516..1606833 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH33_RS08030 (EQH33_08515)	-	1606848..1607744 (-)	897	WP_000825669.1	PEP phosphonomutase	-
EQH33_RS08035 (EQH33_08520)	-	1607747..1609009 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
EQH33_RS08040 (EQH33_08525)	-	1609289..1610467 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
EQH33_RS08045 (EQH33_08530)	-	1610695..1611141 (-)	447	WP_000155418.1	GNAT family N-acetyltransferase	-
EQH33_RS08050 (EQH33_08535)	cclA/cilC	1611211..1611870 (+)	660	WP_000565010.1	A24 family peptidase	Machinery gene
EQH33_RS08055 (EQH33_08540)	trpA	1611842..1612618 (-)	777	WP_001126994.1	tryptophan synthase subunit alpha	-
EQH33_RS08060 (EQH33_08545)	trpB	1612611..1613834 (-)	1224	WP_000331292.1	tryptophan synthase subunit beta	-
EQH33_RS08065 (EQH33_08550)	-	1613812..1614411 (-)	600	WP_000169893.1	phosphoribosylanthranilate isomerase	-
EQH33_RS08070 (EQH33_08555)	trpC	1614398..1615165 (-)	768	WP_000076558.1	indole-3-glycerol phosphate synthase TrpC	-
EQH33_RS08075 (EQH33_08560)	trpD	1615162..1616166 (-)	1005	WP_000658684.1	anthranilate phosphoribosyltransferase	-
EQH33_RS08080 (EQH33_08565)	-	1616177..1616743 (-)	567	WP_000601927.1	aminodeoxychorismate/anthranilate synthase component II	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=337525 EQH33_RS08050 WP_000565010.1 1611211..1611870(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901940]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=337525 EQH33_RS08050 WP_000565010.1 1611211..1611870(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901940]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGTAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877