Detailed information NTG0337295

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH36_RS08330
• Genome accession: NZ_CP035244
• Coordinates: 1648362..1649021 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain TVO_1901945
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1643362..1654021

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH36_RS08305 (EQH36_08740)	-	1643667..1643984 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH36_RS08310 (EQH36_08745)	-	1643999..1644895 (-)	897	WP_000825668.1	PEP phosphonomutase	-
EQH36_RS08315 (EQH36_08750)	-	1644898..1646160 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
EQH36_RS08320 (EQH36_08755)	-	1646440..1647618 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
EQH36_RS08325 (EQH36_08760)	-	1647846..1648292 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH36_RS08330 (EQH36_08765)	cclA/cilC	1648362..1649021 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
EQH36_RS08335 (EQH36_08770)	-	1649073..1650224 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
EQH36_RS08340 (EQH36_08775)	-	1650239..1650970 (-)	732	WP_000934017.1	hypothetical protein	-
EQH36_RS08345 (EQH36_08780)	-	1651196..1651300 (+)	105	Protein_1679	prepilin peptidase	-
EQH36_RS08350 (EQH36_08785)	trpA	1651272..1652048 (-)	777	WP_001127041.1	tryptophan synthase subunit alpha	-
EQH36_RS08355 (EQH36_08790)	trpB	1652041..1653264 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
EQH36_RS08360 (EQH36_08795)	-	1653242..1653841 (-)	600	WP_000169904.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=337295 EQH36_RS08330 WP_000565017.1 1648362..1649021(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901945]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=337295 EQH36_RS08330 WP_000565017.1 1648362..1649021(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901945]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858