Detailed information NTG0337062

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH39_RS07865
• Genome accession: NZ_CP035241
• Coordinates: 1570062..1570721 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565001.1
• Uniprot ID: A0A0B7M7B9
• Organism: Streptococcus pneumoniae strain TVO_1901948
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1565062..1575721

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH39_RS07840 (EQH39_08260)	-	1565367..1565684 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH39_RS07845 (EQH39_08265)	-	1565699..1566595 (-)	897	WP_000825667.1	PEP phosphonomutase	-
EQH39_RS07850 (EQH39_08270)	-	1566598..1567860 (-)	1263	WP_000413343.1	PTS sugar transporter subunit IIC	-
EQH39_RS07855 (EQH39_08275)	-	1568140..1569318 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
EQH39_RS07860 (EQH39_08280)	-	1569546..1569992 (-)	447	WP_000155399.1	GNAT family N-acetyltransferase	-
EQH39_RS07865 (EQH39_08285)	cclA/cilC	1570062..1570721 (+)	660	WP_000565001.1	A24 family peptidase	Machinery gene
EQH39_RS07870 (EQH39_08290)	-	1570773..1571924 (-)	1152	WP_000481756.1	XRE family transcriptional regulator	-
EQH39_RS07875 (EQH39_08295)	-	1571939..1572670 (-)	732	WP_000934017.1	hypothetical protein	-
EQH39_RS07880 (EQH39_08300)	-	1572890..1573000 (+)	111	Protein_1574	prepilin peptidase	-
EQH39_RS07885 (EQH39_08305)	trpA	1572972..1573748 (-)	777	WP_001127015.1	tryptophan synthase subunit alpha	-
EQH39_RS07890 (EQH39_08310)	trpB	1573741..1574964 (-)	1224	WP_000331260.1	tryptophan synthase subunit beta	-
EQH39_RS07895 (EQH39_08315)	-	1574942..1575541 (-)	600	WP_000169898.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24820.92 Da
• Isoelectric Point: 7.2761

>NTDB_id=337062 EQH39_RS07865 WP_000565001.1 1570062..1570721(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901948]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=337062 EQH39_RS07865 WP_000565001.1 1570062..1570721(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901948]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTACTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M7B9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	98.174	100	0.982
cclA/cilC	Streptococcus pneumoniae Rx1	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae D39	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae R6	96.804	100	0.968
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872