Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   EQH43_RS08265 Genome accession   NZ_CP035237
Coordinates   1644993..1645652 (+) Length   219 a.a.
NCBI ID   WP_000565017.1    Uniprot ID   A0A0E8GKN8
Organism   Streptococcus pneumoniae strain TVO_Taiwan19F-14     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1639993..1650652
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH43_RS08225 (EQH43_08650) mgaSpn 1640149..1641630 (-) 1482 WP_001205287.1 virulence factor transcriptional regulator MgaSpn -
  EQH43_RS08230 (EQH43_08655) - 1642073..1642237 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  EQH43_RS08235 (EQH43_08660) amaP 1642321..1642887 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  EQH43_RS08240 (EQH43_08665) - 1642899..1643069 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  EQH43_RS08245 (EQH43_08670) - 1643108..1643716 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  EQH43_RS08250 (EQH43_08675) - 1643747..1643950 (+) 204 WP_000109957.1 CsbD family protein -
  EQH43_RS08255 (EQH43_08680) - 1644060..1644299 (-) 240 WP_001005783.1 transposase -
  EQH43_RS08260 (EQH43_08685) - 1644477..1644923 (-) 447 WP_000155421.1 GNAT family N-acetyltransferase -
  EQH43_RS08265 (EQH43_08690) cclA/cilC 1644993..1645652 (+) 660 WP_000565017.1 A24 family peptidase Machinery gene
  EQH43_RS08270 (EQH43_08695) - 1645704..1646855 (-) 1152 WP_000481747.1 ImmA/IrrE family metallo-endopeptidase -
  EQH43_RS08275 (EQH43_08700) - 1646870..1647601 (-) 732 WP_000934017.1 hypothetical protein -
  EQH43_RS08280 (EQH43_08705) - 1647821..1647931 (+) 111 Protein_1657 prepilin peptidase -
  EQH43_RS08285 (EQH43_08710) trpA 1647903..1648679 (-) 777 WP_001127048.1 tryptophan synthase subunit alpha -
  EQH43_RS08290 (EQH43_08715) trpB 1648672..1649895 (-) 1224 WP_000331287.1 tryptophan synthase subunit beta -
  EQH43_RS08295 (EQH43_08720) - 1649873..1650472 (-) 600 WP_000169887.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24879.99 Da        Isoelectric Point: 7.6418

>NTDB_id=336829 EQH43_RS08265 WP_000565017.1 1644993..1645652(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=336829 EQH43_RS08265 WP_000565017.1 1644993..1645652(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8GKN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae Rx1

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae D39

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae R6

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

85.845

100

0.858

Multiple sequence alignment