Detailed information NTG0336754

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH44_RS08260
• Genome accession: NZ_CP035236
• Coordinates: 1653021..1653680 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain TVO_1902282
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1648021..1658680

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH44_RS08235 (EQH44_08720)	-	1648326..1648643 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH44_RS08240 (EQH44_08725)	-	1648658..1649554 (-)	897	WP_000825668.1	PEP phosphonomutase	-
EQH44_RS08245 (EQH44_08730)	-	1649557..1650819 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
EQH44_RS08250 (EQH44_08735)	-	1651099..1652277 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
EQH44_RS08255 (EQH44_08740)	-	1652505..1652951 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH44_RS08260 (EQH44_08745)	cclA/cilC	1653021..1653680 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
EQH44_RS08265 (EQH44_08750)	-	1653732..1654883 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
EQH44_RS08270 (EQH44_08755)	-	1654898..1655629 (-)	732	WP_000934017.1	hypothetical protein	-
EQH44_RS08275 (EQH44_08760)	-	1655855..1655959 (+)	105	Protein_1665	prepilin peptidase	-
EQH44_RS08280 (EQH44_08765)	trpA	1655931..1656707 (-)	777	WP_001127002.1	tryptophan synthase subunit alpha	-
EQH44_RS08285 (EQH44_08770)	trpB	1656700..1657923 (-)	1224	WP_000331293.1	tryptophan synthase subunit beta	-
EQH44_RS08290 (EQH44_08775)	-	1657901..1658500 (-)	600	WP_000169927.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=336754 EQH44_RS08260 WP_000565017.1 1653021..1653680(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1902282]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=336754 EQH44_RS08260 WP_000565017.1 1653021..1653680(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1902282]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858