Detailed information NTG0336679

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH45_RS08580
• Genome accession: NZ_CP035235
• Coordinates: 1697783..1698442 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain TVO_1902276
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1692783..1703442

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH45_RS08555 (EQH45_09000)	-	1693088..1693405 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH45_RS08560 (EQH45_09005)	-	1693420..1694316 (-)	897	WP_000825668.1	PEP phosphonomutase	-
EQH45_RS08565 (EQH45_09010)	-	1694319..1695581 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
EQH45_RS08570 (EQH45_09015)	-	1695861..1697039 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
EQH45_RS08575 (EQH45_09020)	-	1697267..1697713 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH45_RS08580 (EQH45_09025)	cclA/cilC	1697783..1698442 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
EQH45_RS08585 (EQH45_09030)	-	1698494..1699645 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
EQH45_RS08590 (EQH45_09035)	-	1699660..1700391 (-)	732	WP_000934017.1	hypothetical protein	-
EQH45_RS08595 (EQH45_09040)	-	1700617..1700721 (+)	105	Protein_1724	prepilin peptidase	-
EQH45_RS08600 (EQH45_09045)	trpA	1700693..1701469 (-)	777	WP_001127041.1	tryptophan synthase subunit alpha	-
EQH45_RS08605 (EQH45_09050)	trpB	1701462..1702685 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
EQH45_RS08610 (EQH45_09055)	-	1702663..1703262 (-)	600	WP_000169904.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=336679 EQH45_RS08580 WP_000565017.1 1697783..1698442(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1902276]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=336679 EQH45_RS08580 WP_000565017.1 1697783..1698442(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1902276]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858