Detailed information NTG0336603

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH46_RS08380
• Genome accession: NZ_CP035234
• Coordinates: 1659631..1660290 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain TVO_1902277
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1654631..1665290

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH46_RS08355 (EQH46_08780)	-	1654936..1655253 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH46_RS08360 (EQH46_08785)	-	1655268..1656164 (-)	897	WP_000825668.1	PEP phosphonomutase	-
EQH46_RS08365 (EQH46_08790)	-	1656167..1657429 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
EQH46_RS08370 (EQH46_08795)	-	1657709..1658887 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
EQH46_RS08375 (EQH46_08800)	-	1659115..1659561 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH46_RS08380 (EQH46_08805)	cclA/cilC	1659631..1660290 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
EQH46_RS08385 (EQH46_08810)	-	1660342..1661493 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
EQH46_RS08390 (EQH46_08815)	-	1661508..1662239 (-)	732	WP_000934017.1	hypothetical protein	-
EQH46_RS08395 (EQH46_08820)	-	1662465..1662569 (+)	105	Protein_1688	prepilin peptidase	-
EQH46_RS08400 (EQH46_08825)	trpA	1662541..1663317 (-)	777	WP_001127041.1	tryptophan synthase subunit alpha	-
EQH46_RS08405 (EQH46_08830)	trpB	1663310..1664533 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
EQH46_RS08410 (EQH46_08835)	-	1664511..1665110 (-)	600	WP_000169904.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=336603 EQH46_RS08380 WP_000565017.1 1659631..1660290(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1902277]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=336603 EQH46_RS08380 WP_000565017.1 1659631..1660290(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1902277]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858