Detailed information NTG0033320

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: SP70585_RS09285
• Genome accession: NC_012468
• Coordinates: 1735850..1736509 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565021.1
• Uniprot ID: C1C962
• Organism: Streptococcus pneumoniae 70585
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1730850..1741509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP70585_RS09260 (SP70585_1864)	-	1731155..1731472 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
SP70585_RS09265 (SP70585_1865)	-	1731487..1732383 (-)	897	WP_000825662.1	PEP phosphonomutase	-
SP70585_RS09270 (SP70585_1866)	-	1732386..1733648 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
SP70585_RS09275 (SP70585_1867)	-	1733928..1735106 (+)	1179	WP_000175875.1	ROK family transcriptional regulator	-
SP70585_RS09280 (SP70585_1868)	-	1735334..1735780 (-)	447	WP_000155418.1	GNAT family N-acetyltransferase	-
SP70585_RS09285 (SP70585_1869)	cclA/cilC	1735850..1736509 (+)	660	WP_000565021.1	A24 family peptidase	Machinery gene
SP70585_RS09290 (SP70585_1870)	-	1736561..1737712 (-)	1152	WP_000481746.1	XRE family transcriptional regulator	-
SP70585_RS09295 (SP70585_1871)	-	1737727..1738458 (-)	732	WP_000934017.1	hypothetical protein	-
SP70585_RS12800	-	1738678..1738788 (+)	111	Protein_1779	prepilin peptidase	-
SP70585_RS09300 (SP70585_1872)	trpA	1738760..1739536 (-)	777	WP_001126998.1	tryptophan synthase subunit alpha	-
SP70585_RS09305 (SP70585_1873)	trpB	1739529..1740752 (-)	1224	WP_000331293.1	tryptophan synthase subunit beta	-
SP70585_RS09310 (SP70585_1874)	-	1740730..1741329 (-)	600	WP_000169894.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24854.98 Da
• Isoelectric Point: 7.9575

>NTDB_id=33320 SP70585_RS09285 WP_000565021.1 1735850..1736509(+) (cclA/cilC) [Streptococcus pneumoniae 70585]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=33320 SP70585_RS09285 WP_000565021.1 1735850..1736509(+) (cclA/cilC) [Streptococcus pneumoniae 70585]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTAGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: C1C962

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae D39	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae R6	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae TIGR4	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	93.151	100	0.932
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877