Detailed information NTG0033203

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SPJ_RS13640
• Genome accession: NC_012466
• Coordinates: 480025..480612 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae JJA
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 475025..485612

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPJ_RS02490 (SPJ_0493)	-	475487..476827 (+)	1341	WP_001017642.1	sensor histidine kinase	-
SPJ_RS02495 (SPJ_0494)	blpC	476898..477026 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
SPJ_RS02500 (SPJ_0495)	-	477083..478444 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
SPJ_RS02505 (SPJ_0496)	comA/nlmT	478455..480131 (-)	1677	WP_196300924.1	peptide cleavage/export ABC transporter	Regulator
SPJ_RS13640	comA/nlmT	480025..480612 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
SPJ_RS02515 (SPJ_0498)	blpM	480894..481148 (+)	255	WP_001093256.1	two-peptide bacteriocin subunit BlpM	-
SPJ_RS02520 (SPJ_0499)	blpN	481164..481367 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
SPJ_RS02525 (SPJ_0500)	cipB	481611..481760 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
SPJ_RS02530 (SPJ_0502)	-	481864..481983 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
SPJ_RS11585 (SPJ_0503)	-	482281..482445 (+)	165	WP_000727117.1	hypothetical protein	-
SPJ_RS11590 (SPJ_0504)	-	482507..482845 (+)	339	WP_088804618.1	immunity protein	-
SPJ_RS02550 (SPJ_0506)	-	483474..483857 (+)	384	WP_000877381.1	hypothetical protein	-
SPJ_RS02555 (SPJ_0507)	-	483909..484598 (+)	690	WP_000760520.1	CPBP family intramembrane glutamic endopeptidase	-
SPJ_RS02560 (SPJ_0508)	blpZ	484640..484888 (+)	249	WP_000276501.1	immunity protein BlpZ	-
SPJ_RS02565 (SPJ_0509)	-	484918..485529 (+)	612	WP_000394043.1	type II CAAX endopeptidase family protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=33203 SPJ_RS13640 WP_000205166.1 480025..480612(-) (comA/nlmT) [Streptococcus pneumoniae JJA]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=33203 SPJ_RS13640 WP_000205166.1 480025..480612(-) (comA/nlmT) [Streptococcus pneumoniae JJA]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497