Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SUB_RS02010 Genome accession   NC_012004
Coordinates   376621..377307 (+) Length   228 a.a.
NCBI ID   WP_012657914.1    Uniprot ID   B9DTP8
Organism   Streptococcus uberis 0140J     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 371621..382307
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SUB_RS01985 (SUB0372) ktrB 371844..373235 (-) 1392 WP_269441091.1 potassium uptake transporter channel subunit KtrB -
  SUB_RS01990 (SUB0373) rsmG 373307..374020 (-) 714 WP_012657909.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  SUB_RS01995 (SUB0375) - 374167..374724 (+) 558 WP_012657910.1 LemA family protein -
  SUB_RS02000 (SUB0376) htpX 374759..375652 (+) 894 WP_012657911.1 zinc metalloprotease HtpX -
  SUB_RS02005 (SUB0377) - 375865..376398 (+) 534 WP_012657912.1 YceD family protein -
  SUB_RS02010 (SUB0379) covR 376621..377307 (+) 687 WP_012657914.1 two-component system response regulator CovR Regulator
  SUB_RS02015 (SUB0380) - 377311..378813 (+) 1503 WP_012657915.1 HAMP domain-containing sensor histidine kinase -
  SUB_RS02020 (SUB0381) nrdR 378976..379470 (+) 495 WP_012657916.1 transcriptional regulator NrdR -
  SUB_RS02025 (SUB0382) - 379454..380650 (+) 1197 WP_012657917.1 DnaD domain protein -
  SUB_RS02030 (SUB0383) dnaI 380651..381553 (+) 903 WP_012657918.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26623.61 Da        Isoelectric Point: 4.6541

>NTDB_id=32913 SUB_RS02010 WP_012657914.1 376621..377307(+) (covR) [Streptococcus uberis 0140J]
MTKKILIVEDEKNLARFVSLELQHEGYEVTVEVNGREGLETALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIETEKKAPNQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMSNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDMPGRESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=32913 SUB_RS02010 WP_012657914.1 376621..377307(+) (covR) [Streptococcus uberis 0140J]
ATGACAAAGAAAATTTTAATCGTTGAAGATGAGAAAAATCTTGCGAGATTTGTATCTTTAGAATTACAACATGAAGGTTA
TGAAGTAACAGTCGAGGTAAATGGGCGTGAAGGTTTAGAAACGGCTCTTGAAAAAGACTTTGATTTAATCCTTTTAGATT
TAATGTTACCTGAAATGGATGGTTTTGAAGTGACACGTCGCTTACAGACTGAGAAAACAACCTATATCATGATGATGACT
GCACGTGATTCTATCATGGATGTCGTGGCAGGTTTAGACCGTGGTGCGGATGATTATATTGTTAAACCATTTGCCATTGA
AGAGTTATTAGCACGTATCAGAGCGATTTTCCGTCGTCAAGACATTGAAACAGAGAAGAAAGCTCCCAATCAAGGAATCT
ATCGTGATTTAGTTTTAAATCCACAAAATCGTTCAGTCAACCGTGGTGATGATGAAATTTCATTAACAAAACGTGAATAT
GATTTGTTAAATATTCTTATGTCAAATATGAACCGTGTTATGACACGTGAAGAATTATTATCAAACGTTTGGAAATATGA
CGAAGCAGTGGAAACAAATGTTGTTGATGTCTATATTCGTTACCTTCGTGGAAAAATTGACATGCCTGGAAGAGAGTCAT
ACATTCAAACAGTTCGTGGAATGGGATACGTAATTCGCGAGAAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B9DTP8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

83.406

100

0.838
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.723

100

0.443
  micA Streptococcus pneumoniae Cp1015

43.478

100

0.439

Multiple sequence alignment