Detailed information NTG0325985

Bioinformatically predicted

Overview

• Name: comK/comK1
• Type: Regulator
• Locus tag: EGX85_RS02885
• Genome accession: NZ_CP033814
• Coordinates: 556369..556953 (+)
• Length: 194 a.a.
• NCBI ID: WP_011276196.1
• Uniprot ID: A0A2A1KAP4
• Organism: Staphylococcus haemolyticus strain FDAARGOS_517
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	554709..564686	556369..556953	within	0
IScluster/Tn	557051..564686	556369..556953	flank	98

Gene organization within MGE regions

Location: 554709..564686

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX85_RS02870 (EGX85_02875)	-	554709..555263 (-)	555	WP_011276192.1	GNAT family N-acetyltransferase	-
EGX85_RS02875 (EGX85_02880)	-	555450..555680 (+)	231	WP_016931370.1	TM2 domain-containing protein	-
EGX85_RS13340	-	555759..555860 (+)	102	WP_011276194.1	SAR1012 family small protein	-
EGX85_RS02880 (EGX85_02885)	-	555937..556155 (-)	219	WP_011276195.1	IDEAL domain-containing protein	-
EGX85_RS02885 (EGX85_02890)	comK/comK1	556369..556953 (+)	585	WP_011276196.1	competence protein ComK	Regulator
EGX85_RS02890 (EGX85_02895)	-	557051..558366 (-)	1316	Protein_541	ISL3-like element ISSha1 family transposase	-
EGX85_RS13575	-	559360..559482 (+)	123	WP_255201521.1	hypothetical protein	-
EGX85_RS13345	-	559534..559641 (+)	108	Protein_543	hypothetical protein	-
EGX85_RS13350	-	559648..559869 (+)	222	WP_229689269.1	SHOCT domain-containing protein	-
EGX85_RS02910 (EGX85_02915)	-	559904..560479 (+)	576	WP_046464885.1	hypothetical protein	-
EGX85_RS02915 (EGX85_02920)	-	560567..560650 (+)	84	WP_227528431.1	Ltp family lipoprotein	-
EGX85_RS02920 (EGX85_02925)	-	560698..561687 (-)	990	WP_046464886.1	lipoate--protein ligase	-
EGX85_RS02925 (EGX85_02930)	-	561888..562064 (+)	177	WP_011276202.1	DUF2187 family protein	-
EGX85_RS02930 (EGX85_02935)	-	562081..562683 (+)	603	WP_011276203.1	CPBP family glutamic-type intramembrane protease	-
EGX85_RS02935 (EGX85_02940)	-	562973..564686 (+)	1714	Protein_550	IS1182 family transposase	-

Sequence

Protein

• Length: 194 a.a.
• Molecular weight: 23002.43 Da
• Isoelectric Point: 9.2942

>NTDB_id=325985 EGX85_RS02885 WP_011276196.1 556369..556953(+) (comK/comK1) [Staphylococcus haemolyticus strain FDAARGOS_517]
MTNISQSQNTVYIIRKGDMIIKPVIDDYEQTKGSEIWKYDSTIVSSPFKTQKIVERSCKFYGNSYISKKSETQRIAGITS
KPPILLTPLFPTYFFPTHSDRLEENMWINMHYVHEIKPLKNRKCKIIFANHQTLTLNVSYHSIWHQYSNCIFYYYMVDKQ
SRMKSNNPEMPIDYEKTTLNIFEALSHYSLLQDK

Nucleotide

• Length: 585 bp

>NTDB_id=325985 EGX85_RS02885 WP_011276196.1 556369..556953(+) (comK/comK1) [Staphylococcus haemolyticus strain FDAARGOS_517]
ATGACAAATATTTCTCAAAGCCAAAATACTGTATATATTATTCGAAAAGGAGATATGATAATCAAACCCGTCATTGATGA
TTATGAGCAAACAAAAGGATCAGAAATATGGAAATATGATTCCACAATAGTTTCAAGCCCATTCAAAACTCAAAAAATCG
TCGAACGCTCATGTAAATTTTATGGTAATAGCTATATTAGTAAGAAATCCGAAACACAACGAATTGCCGGCATTACTAGT
AAACCACCTATTTTATTGACTCCTCTCTTCCCCACTTATTTTTTCCCTACACATTCAGACCGTTTAGAAGAAAACATGTG
GATTAATATGCATTATGTACATGAAATTAAACCTCTTAAAAATCGAAAATGTAAAATTATTTTTGCAAATCATCAAACAT
TAACACTTAATGTTTCCTACCACAGTATTTGGCACCAATACTCTAACTGCATTTTTTATTATTACATGGTCGATAAACAA
TCTCGTATGAAGTCAAACAATCCAGAAATGCCAATAGATTATGAGAAAACGACTTTAAATATTTTCGAAGCACTTTCACA
TTATTCACTATTACAAGATAAATAG

Domains

Predicted by InterproScan.

• ComK protein (ComK) (11-161)

3D structure

• AlphaFold DB: A0A2A1KAP4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comK/comK1	Staphylococcus aureus MW2	68.617	96.907	0.665
comK/comK1	Staphylococcus aureus N315	68.617	96.907	0.665