Detailed information NTG0325601

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: IHMA87_RS12505
• Genome accession: NZ_CP041354
• Coordinates: 2581613..2582284 (+)
• Length: 223 a.a.
• NCBI ID: WP_012075424.1
• Uniprot ID: A0A2R3IV09
• Organism: Pseudomonas aeruginosa strain AZPAE15042
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2576613..2587284

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IHMA87_RS12470 (IHMA87_02446)	ppyR	2577102..2577359 (+)	258	WP_003157851.1	psl/pyoverdine operon transcriptional regulator PpyR	-
IHMA87_RS12475 (IHMA87_02447)	-	2577346..2578539 (+)	1194	WP_034082247.1	NnrS family protein	-
IHMA87_RS12480 (IHMA87_02448)	-	2578540..2578806 (-)	267	WP_034082273.1	DUF5329 domain-containing protein	-
IHMA87_RS12485 (IHMA87_02449)	-	2578790..2579683 (-)	894	WP_034082246.1	hypothetical protein	-
IHMA87_RS12490 (IHMA87_02450)	-	2579710..2580792 (-)	1083	WP_034082244.1	hypothetical protein	-
IHMA87_RS12495 (IHMA87_02451)	-	2580991..2581299 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
IHMA87_RS12500 (IHMA87_02452)	-	2581299..2581613 (+)	315	WP_033996695.1	PepSY domain-containing protein	-
IHMA87_RS12505 (IHMA87_02453)	ciaR	2581613..2582284 (+)	672	WP_012075424.1	two-component system response regulator CarR	Regulator
IHMA87_RS12510 (IHMA87_02454)	carS	2582281..2583615 (+)	1335	WP_012075425.1	two-component system sensor histidine kinase CarS	-
IHMA87_RS12515 (IHMA87_02455)	-	2583707..2584015 (+)	309	WP_034082242.1	hypothetical protein	-
IHMA87_RS33230	-	2584020..2584556 (-)	537	Protein_2427	methyl-accepting chemotaxis protein	-
IHMA87_RS33235	-	2584926..2586164 (-)	1239	Protein_2428	chemotaxis protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24626.06 Da
• Isoelectric Point: 5.8445

>NTDB_id=325601 IHMA87_RS12505 WP_012075424.1 2581613..2582284(+) (ciaR) [Pseudomonas aeruginosa strain AZPAE15042]
MRLLLVEDHVPLADELLASLGRQGYAVDWLADGRDAALQGASEPYDLIILDLGLPGRPGLEILREWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLSLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAGG

Nucleotide

• Length: 672 bp

>NTDB_id=325601 IHMA87_RS12505 WP_012075424.1 2581613..2582284(+) (ciaR) [Pseudomonas aeruginosa strain AZPAE15042]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCGCTGGCCGACGAACTTCTGGCCAGCCTGGGCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGCTGCAGGGCGCCAGCGAACCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCTGGCCGCCCCGGCCTGGAGATCCTCCGGGAATGGCGCGGCCTGGGCCTCGCCACCCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAGCGCATCGACGGGCTCAAGGCCGGCGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
ACTGGCCCTGCGCATCCAGGCCCTGTTGCGCCGCGCCCACGGCCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTCA
GCCTCGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGTGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGACACCTGGCCGAGCATCTGTACGATGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGTCGCGAGGTGATCGAGACCCGCCGTGGGCAGG
GCTACCGCTACGCCGGGGTGGCCGGCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A2R3IV09

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
vicR	Streptococcus mutans UA159	35.526	100	0.363