Detailed information NTG0325485

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EGX78_RS00470
• Genome accession: NZ_CP033767
• Coordinates: 80568..81479 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain FDAARGOS_534
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 75568..86479

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX78_RS00450 (EGX78_00450)	purE	75862..76353 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EGX78_RS00455 (EGX78_00455)	purK	76340..77413 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EGX78_RS00460 (EGX78_00460)	-	77434..78774 (+)	1341	WP_002987721.1	hypothetical protein	-
EGX78_RS00465 (EGX78_00465)	purB	79143..80435 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
EGX78_RS00470 (EGX78_00470)	comR	80568..81479 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
EGX78_RS09735	comS	81563..81658 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
EGX78_RS00475 (EGX78_00475)	ruvB	81705..82703 (+)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
EGX78_RS00480 (EGX78_00480)	-	82841..83278 (+)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
EGX78_RS00485 (EGX78_00485)	-	83302..83703 (+)	402	WP_002987730.1	MORN repeat-containing protein	-
EGX78_RS00490 (EGX78_00490)	-	83700..85475 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=325485 EGX78_RS00470 WP_002986681.1 80568..81479(+) (comR) [Streptococcus pyogenes strain FDAARGOS_534]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=325485 EGX78_RS00470 WP_002986681.1 80568..81479(+) (comR) [Streptococcus pyogenes strain FDAARGOS_534]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462