Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   D8S76_RS00330 Genome accession   NZ_CP032699
Coordinates   53454..54356 (+) Length   300 a.a.
NCBI ID   WP_032460886.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY155     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48454..59356
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D8S76_RS00310 (D8S76_00310) purE 48738..49229 (+) 492 WP_023079042.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  D8S76_RS00315 (D8S76_00315) purK 49216..50289 (+) 1074 WP_023079033.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  D8S76_RS00320 (D8S76_00320) - 50316..52013 (+) 1698 WP_115224516.1 AIPR family protein -
  D8S76_RS00325 (D8S76_00325) purB 52031..53323 (+) 1293 WP_023079043.1 adenylosuccinate lyase -
  D8S76_RS00330 (D8S76_00330) comR 53454..54356 (+) 903 WP_032460886.1 transcriptional regulator Rgg4/ComR Regulator
  D8S76_RS09860 comS 54440..54535 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  D8S76_RS00335 (D8S76_00335) ruvB 54582..55580 (+) 999 WP_014407198.1 Holliday junction branch migration DNA helicase RuvB -
  D8S76_RS00340 (D8S76_00340) - 55718..56155 (+) 438 WP_023079047.1 low molecular weight protein-tyrosine-phosphatase -
  D8S76_RS00345 (D8S76_00345) - 56178..56579 (+) 402 WP_032465955.1 MORN repeat-containing protein -
  D8S76_RS00350 (D8S76_00350) - 56576..58351 (+) 1776 WP_023079046.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 300 a.a.        Molecular weight: 35352.85 Da        Isoelectric Point: 4.5164

>NTDB_id=318241 D8S76_RS00330 WP_032460886.1 53454..54356(+) (comR) [Streptococcus pyogenes strain TSPY155]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMAKIQ
DWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 903 bp        

>NTDB_id=318241 D8S76_RS00330 WP_032460886.1 53454..54356(+) (comR) [Streptococcus pyogenes strain TSPY155]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTGATATTTCAT
CACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCGAAAATTCAA
GATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAATAAAAGCAGA
ACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTCAAGAGTGGG
AAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-293)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.01

100

1
  comR Streptococcus pyogenes MGAS315

58.472

100

0.587
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.546

97

0.5
  comR Streptococcus mutans UA159

46.358

100

0.467

Multiple sequence alignment