Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   D5R90_RS02890 Genome accession   NZ_CP032400
Coordinates   582339..583025 (-) Length   228 a.a.
NCBI ID   WP_003101668.1    Uniprot ID   -
Organism   Streptococcus iniae strain YM011     
Function   repress comR expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 571110..598169 582339..583025 within 0


Gene organization within MGE regions


Location: 571110..598169
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D5R90_RS02845 (D5R90_02845) - 571701..572662 (-) 962 Protein_565 IS3 family transposase -
  D5R90_RS02850 (D5R90_02850) - 572719..572826 (+) 108 Protein_566 IS30 family transposase -
  D5R90_RS02855 (D5R90_02855) - 573186..573386 (-) 201 WP_003101659.1 cold-shock protein -
  D5R90_RS02860 (D5R90_02860) - 573524..576613 (-) 3090 WP_016356109.1 DEAD/DEAH box helicase -
  D5R90_RS02865 (D5R90_02865) der 576771..578081 (-) 1311 WP_003101663.1 ribosome biogenesis GTPase Der -
  D5R90_RS02870 (D5R90_02870) dnaI 578132..579034 (-) 903 WP_003101664.1 primosomal protein DnaI -
  D5R90_RS02875 (D5R90_02875) - 579035..580222 (-) 1188 WP_003101665.1 DnaD domain protein -
  D5R90_RS02880 (D5R90_02880) nrdR 580206..580700 (-) 495 WP_003101666.1 transcriptional regulator NrdR -
  D5R90_RS02885 (D5R90_02885) - 580846..582336 (-) 1491 WP_064537873.1 HAMP domain-containing histidine kinase -
  D5R90_RS02890 (D5R90_02890) covR 582339..583025 (-) 687 WP_003101668.1 two-component system response regulator CovR Regulator
  D5R90_RS02895 (D5R90_02895) - 583254..583787 (-) 534 WP_003101669.1 DUF177 domain-containing protein -
  D5R90_RS02900 (D5R90_02900) htpX 583975..584871 (-) 897 WP_003101670.1 zinc metalloprotease HtpX -
  D5R90_RS02905 (D5R90_02905) - 584910..585467 (-) 558 WP_003101671.1 LemA family protein -
  D5R90_RS02910 (D5R90_02910) rsmG 585612..586328 (+) 717 WP_003101672.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  D5R90_RS02915 (D5R90_02915) ktrB 586420..587781 (+) 1362 WP_017794720.1 potassium uptake transporter channel subunit KtrB -
  D5R90_RS02920 (D5R90_02920) ktrA 587791..588465 (+) 675 WP_003101682.1 potassium uptake transporter gating subunit KtrA -
  D5R90_RS02925 (D5R90_02925) sstT 588653..589861 (-) 1209 WP_003101683.1 serine/threonine transporter SstT -
  D5R90_RS02930 (D5R90_02930) brnQ 590071..591438 (+) 1368 WP_003101684.1 branched-chain amino acid transport system II carrier protein -
  D5R90_RS02935 (D5R90_02935) - 591771..592460 (-) 690 WP_003101685.1 methionine ABC transporter permease -
  D5R90_RS02940 (D5R90_02940) - 592464..593528 (-) 1065 WP_003101686.1 methionine ABC transporter ATP-binding protein -
  D5R90_RS02945 (D5R90_02945) - 593521..594897 (-) 1377 WP_003101687.1 M20/M25/M40 family metallo-hydrolase -
  D5R90_RS02950 (D5R90_02950) - 594958..595803 (-) 846 WP_016356113.1 MetQ/NlpA family ABC transporter substrate-binding protein -
  D5R90_RS02955 (D5R90_02955) - 595952..596782 (-) 831 WP_162911859.1 amino acid ABC transporter substrate-binding protein -
  D5R90_RS02960 (D5R90_02960) - 596925..597641 (-) 717 WP_003101691.1 YebC/PmpR family DNA-binding transcriptional regulator -
  D5R90_RS02965 (D5R90_02965) - 597804..598169 (-) 366 WP_003101694.1 PH domain-containing protein -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26670.62 Da        Isoelectric Point: 4.6541

>NTDB_id=315430 D5R90_RS02890 WP_003101668.1 582339..583025(-) (covR) [Streptococcus iniae strain YM011]
MTKKILIVEDEKNLARFVSLELQHEGYEVTVEVNGREGLDTALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIETEKKSPNQGIYRDLVLNPQNRSVNRGDEEISLTKREY
DLLNILMSNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDMQGRESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=315430 D5R90_RS02890 WP_003101668.1 582339..583025(-) (covR) [Streptococcus iniae strain YM011]
ATGACAAAAAAAATTCTAATTGTTGAAGATGAAAAAAATCTTGCAAGGTTTGTTTCATTAGAATTGCAACACGAAGGTTA
CGAAGTAACTGTAGAAGTGAATGGTCGTGAAGGACTTGACACAGCGCTTGAAAAAGATTTTGATTTAATCTTGCTTGATT
TGATGTTACCTGAAATGGATGGTTTTGAAGTGACCCGTCGTCTTCAAACTGAAAAAACAACCTACATTATGATGATGACA
GCACGCGATTCTATCATGGACGTGGTTGCTGGTTTGGATCGTGGTGCAGATGATTATATTGTTAAGCCATTTGCTATTGA
AGAATTATTGGCACGTATTCGTGCAATTTTCCGTCGTCAAGATATTGAAACTGAGAAAAAATCTCCTAATCAAGGTATTT
ACCGTGATTTAGTCTTAAATCCACAAAACCGTTCTGTAAACCGTGGAGATGAAGAAATTTCATTGACAAAACGCGAATAT
GATTTGTTAAACATTTTAATGAGCAATATGAATCGTGTCATGACGCGTGAAGAGTTGCTGTCAAATGTTTGGAAATACGA
TGAAGCTGTTGAAACAAACGTTGTTGACGTGTATATTCGTTACCTACGTGGAAAAATCGATATGCAAGGACGTGAGTCCT
ATATTCAAACTGTTCGTGGAATGGGATATGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.533

100

0.829
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.29

100

0.439
  micA Streptococcus pneumoniae Cp1015

43.043

100

0.434

Multiple sequence alignment