Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DZN22_RS08345 Genome accession   NZ_CP031637
Coordinates   1623070..1623756 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS10786     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1618070..1628756
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DZN22_RS08325 (DZN22_08315) dnaI 1618791..1619693 (-) 903 WP_011284517.1 primosomal protein DnaI -
  DZN22_RS08330 (DZN22_08320) - 1619694..1620869 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  DZN22_RS08335 (DZN22_08325) nrdR 1620853..1621347 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DZN22_RS08340 (DZN22_08330) covS 1621562..1623064 (-) 1503 WP_011284516.1 two-component system sensor histidine kinase CovS -
  DZN22_RS08345 (DZN22_08335) covR 1623070..1623756 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DZN22_RS08350 (DZN22_08340) - 1624023..1624556 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  DZN22_RS08355 (DZN22_08345) htpX 1624790..1625686 (-) 897 WP_011284515.1 zinc metalloprotease HtpX -
  DZN22_RS08360 (DZN22_08350) - 1625733..1626290 (-) 558 WP_002985956.1 LemA family protein -
  DZN22_RS08365 (DZN22_08355) rsmG 1626440..1627153 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DZN22_RS08370 (DZN22_08360) ktrB 1627238..1628614 (+) 1377 WP_032459750.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=309073 DZN22_RS08345 WP_002991052.1 1623070..1623756(-) (covR) [Streptococcus pyogenes strain MGAS10786]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=309073 DZN22_RS08345 WP_002991052.1 1623070..1623756(-) (covR) [Streptococcus pyogenes strain MGAS10786]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
CGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment