Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   DV129_RS08105 Genome accession   NZ_CP031247
Coordinates   1491625..1492377 (+) Length   250 a.a.
NCBI ID   WP_000866065.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain M23734     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1486625..1497377
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV129_RS08075 spo0J 1487216..1487974 (-) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator
  DV129_RS08080 htrA 1488032..1489213 (-) 1182 WP_000681603.1 S1C family serine protease Regulator
  DV129_RS08085 rlmH 1489396..1489875 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DV129_RS08095 comC/comC1 1490157..1490282 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  DV129_RS08100 comD/comD1 1490303..1491628 (+) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  DV129_RS08105 comE 1491625..1492377 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  DV129_RS08120 - 1492620..1493162 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  DV129_RS12545 - 1493341..1494944 (+) 1604 Protein_1532 YhgE/Pip domain-containing protein -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29958.31 Da        Isoelectric Point: 6.5073

>NTDB_id=304780 DV129_RS08105 WP_000866065.1 1491625..1492377(+) (comE) [Streptococcus pneumoniae strain M23734]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=304780 DV129_RS08105 WP_000866065.1 1491625..1492377(+) (comE) [Streptococcus pneumoniae strain M23734]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

100

100

1
  comE Streptococcus pneumoniae D39

100

100

1
  comE Streptococcus pneumoniae R6

100

100

1
  comE Streptococcus pneumoniae TIGR4

100

100

1
  comE Streptococcus mitis SK321

99.2

100

0.992
  comE Streptococcus mitis NCTC 12261

98.4

100

0.984
  comE Streptococcus infantis strain Atu-4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.8

100

0.628
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.8

100

0.628
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment