Detailed information NTG0304690

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: DV131_RS02200
• Genome accession: NZ_CP031246
• Coordinates: 380765..381472 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166478.1
• Uniprot ID: A0A654UWX8
• Organism: Streptococcus pneumoniae strain M26368
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	379709..380098	380765..381472	flank	667

Gene organization within MGE regions

Location: 379709..381472

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DV131_RS02190	-	379709..380267 (-)	559	Protein_375	transposase	-
DV131_RS02195	-	380253..380681 (+)	429	WP_001863203.1	cupin domain-containing protein	-
DV131_RS02200	vicR	380765..381472 (+)	708	WP_000166478.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27240.59 Da
• Isoelectric Point: 6.6568

>NTDB_id=304690 DV131_RS02200 WP_000166478.1 380765..381472(+) (vicR) [Streptococcus pneumoniae strain M26368]
MTKQVLLVDDEEHILRLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=304690 DV131_RS02200 WP_000166478.1 380765..381472(+) (vicR) [Streptococcus pneumoniae strain M26368]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAGATTACTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGAGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

3D structure

• AlphaFold DB: A0A654UWX8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	41.202	99.149	0.409
covR	Streptococcus salivarius strain HSISS4	40.171	99.574	0.4