Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DV119_RS05675 Genome accession   NZ_CP031245
Coordinates   1027871..1028608 (+) Length   245 a.a.
NCBI ID   WP_050221200.1    Uniprot ID   A0AA44S714
Organism   Streptococcus pneumoniae strain M16808     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1009127..1033860 1027871..1028608 within 0


Gene organization within MGE regions


Location: 1009127..1033860
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV119_RS05590 psrA 1010467..1011264 (+) 798 WP_000651177.1 tyrosine-type DNA invertase PsrA -
  DV119_RS05595 - 1011275..1011883 (+) 609 WP_000240090.1 restriction endonuclease subunit S -
  DV119_RS05600 - 1011831..1013378 (-) 1548 WP_114880816.1 restriction endonuclease subunit S -
  DV119_RS05605 - 1013378..1014841 (-) 1464 WP_054387359.1 HsdM family class I SAM-dependent methyltransferase -
  DV119_RS05610 hsdR 1014854..1017187 (-) 2334 WP_054387360.1 EcoAI/FtnUII family type I restriction enzme subunit R -
  DV119_RS05620 - 1017795..1018304 (+) 510 WP_054387361.1 DUF2812 domain-containing protein -
  DV119_RS05625 hrcA 1018468..1019502 (+) 1035 WP_000255768.1 heat-inducible transcriptional repressor HrcA -
  DV119_RS05630 grpE 1019529..1020053 (+) 525 WP_000046027.1 nucleotide exchange factor GrpE -
  DV119_RS05635 dnaK 1020533..1022356 (+) 1824 WP_000034662.1 molecular chaperone DnaK -
  DV119_RS05640 - 1022358..1022714 (+) 357 WP_000114433.1 hypothetical protein -
  DV119_RS05645 dnaJ 1023116..1024252 (+) 1137 WP_050073039.1 molecular chaperone DnaJ -
  DV119_RS05650 - 1024632..1024919 (-) 288 WP_000777760.1 hypothetical protein -
  DV119_RS05655 - 1024929..1025339 (-) 411 WP_001278301.1 HIT family protein -
  DV119_RS05660 pptA 1025407..1026138 (+) 732 WP_050221198.1 ABC transporter ATP-binding protein Regulator
  DV119_RS05665 - 1026135..1027184 (+) 1050 WP_050221199.1 ABC transporter permease -
  DV119_RS05670 - 1027246..1027575 (-) 330 WP_000132585.1 hypothetical protein -
  DV119_RS05675 comE/blpR 1027871..1028608 (+) 738 WP_050221200.1 response regulator transcription factor Regulator
  DV119_RS05680 - 1028622..1029971 (+) 1350 WP_050221201.1 sensor histidine kinase -
  DV119_RS12160 - 1030205..1030396 (+) 192 WP_376738204.1 hypothetical protein -
  DV119_RS11510 - 1030597..1030761 (+) 165 WP_049511538.1 hypothetical protein -
  DV119_RS05695 - 1030758..1031162 (+) 405 WP_050221203.1 hypothetical protein -
  DV119_RS12165 - 1031433..1031709 (+) 277 Protein_1026 immunity protein -
  DV119_RS05710 - 1031792..1032175 (+) 384 WP_050221205.1 hypothetical protein -
  DV119_RS05715 - 1032240..1032929 (+) 690 WP_050221206.1 CPBP family intramembrane glutamic endopeptidase -
  DV119_RS05720 blpZ 1032971..1033219 (+) 249 WP_050221207.1 immunity protein BlpZ -
  DV119_RS05725 - 1033249..1033860 (+) 612 WP_050221208.1 CPBP family intramembrane glutamic endopeptidase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28828.99 Da        Isoelectric Point: 6.1688

>NTDB_id=304640 DV119_RS05675 WP_050221200.1 1027871..1028608(+) (comE/blpR) [Streptococcus pneumoniae strain M16808]
MRIFVLEDDFSQQTRIETTIEKLLKEHQIVPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=304640 DV119_RS05675 WP_050221200.1 1027871..1028608(+) (comE/blpR) [Streptococcus pneumoniae strain M16808]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAAGAACA
TCAGATCGTTCCCAGCTCTTTTGAAGTTTTTGGTAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCTCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAACGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATCCGGGATCGGGAT
CCTTATGCCTTGATAGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCTGCTCTAGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATA
GTAAAAGTTTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTACATTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.144

99.184

0.547
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

39.669

98.776

0.392
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment