Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   DV119_RS00505 Genome accession   NZ_CP031245
Coordinates   85498..86157 (+) Length   219 a.a.
NCBI ID   WP_000565001.1    Uniprot ID   A0A0B7M7B9
Organism   Streptococcus pneumoniae strain M16808     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 76461..109089 85498..86157 within 0


Gene organization within MGE regions


Location: 76461..109089
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV119_RS00460 - 76461..77309 (-) 849 WP_000782429.1 formylglycine-generating enzyme family protein -
  DV119_RS00465 - 77306..78781 (-) 1476 WP_050096564.1 arylsulfatase -
  DV119_RS00470 - 79104..80459 (-) 1356 WP_001865112.1 PTS sugar transporter subunit IIC -
  DV119_RS00475 - 80469..80786 (-) 318 WP_001005887.1 PTS lactose/cellobiose transporter subunit IIA -
  DV119_RS00480 - 80803..81120 (-) 318 WP_050221104.1 PTS sugar transporter subunit IIB -
  DV119_RS00485 - 81135..82031 (-) 897 WP_001865114.1 hypothetical protein -
  DV119_RS00490 - 82034..83296 (-) 1263 WP_000413342.1 PTS sugar transporter subunit IIC -
  DV119_RS00495 - 83576..84754 (+) 1179 WP_001865373.1 ROK family transcriptional regulator -
  DV119_RS00500 - 84982..85428 (-) 447 WP_000155432.1 GNAT family N-acetyltransferase -
  DV119_RS00505 cclA/cilC 85498..86157 (+) 660 WP_000565001.1 prepilin peptidase Machinery gene
  DV119_RS00510 - 86209..87360 (-) 1152 WP_001865397.1 XRE family transcriptional regulator -
  DV119_RS00515 - 87375..88106 (-) 732 WP_000934016.1 hypothetical protein -
  DV119_RS11435 - 88326..88436 (+) 111 Protein_97 prepilin peptidase -
  DV119_RS00525 trpA 88408..89184 (-) 777 WP_001127027.1 tryptophan synthase subunit alpha -
  DV119_RS00530 trpB 89177..90400 (-) 1224 WP_024477621.1 tryptophan synthase subunit beta -
  DV119_RS00535 - 90378..90977 (-) 600 WP_000169888.1 phosphoribosylanthranilate isomerase -
  DV119_RS00540 trpC 90964..91731 (-) 768 WP_000076548.1 indole-3-glycerol phosphate synthase TrpC -
  DV119_RS00545 trpD 91728..92732 (-) 1005 WP_000658682.1 anthranilate phosphoribosyltransferase -
  DV119_RS00550 - 92743..93309 (-) 567 WP_000601919.1 aminodeoxychorismate/anthranilate synthase component II -
  DV119_RS00555 trpE 93306..94667 (-) 1362 WP_000439654.1 anthranilate synthase component I -
  DV119_RS11235 - 95039..95227 (-) 189 WP_185739684.1 hypothetical protein -
  DV119_RS00565 - 95897..96898 (-) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  DV119_RS00570 - 97006..97374 (-) 369 WP_000656286.1 hypothetical protein -
  DV119_RS00575 - 97470..98180 (-) 711 WP_000127552.1 MgtC/SapB family protein -
  DV119_RS00580 - 98183..99874 (-) 1692 WP_001216185.1 ABC transporter permease -
  DV119_RS00585 - 99886..100896 (-) 1011 WP_050279185.1 ABC transporter ATP-binding protein -
  DV119_RS00590 - 101000..102067 (-) 1068 WP_023930326.1 extracellular solute-binding protein -
  DV119_RS00595 - 102092..102751 (-) 660 WP_000793812.1 DUF1868 domain-containing protein -
  DV119_RS00600 galE 102931..103941 (-) 1011 WP_050198011.1 UDP-glucose 4-epimerase GalE -
  DV119_RS00605 galT 103954..105429 (-) 1476 WP_000848795.1 UDP-glucose--hexose-1-phosphate uridylyltransferase -
  DV119_RS00610 - 105447..106082 (-) 636 WP_050084685.1 phosphate signaling complex PhoU family protein -
  DV119_RS11650 - 106140..106523 (-) 384 WP_001812628.1 hypothetical protein -
  DV119_RS00620 - 106683..106979 (-) 297 WP_000239027.1 hypothetical protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24820.92 Da        Isoelectric Point: 7.2761

>NTDB_id=304590 DV119_RS00505 WP_000565001.1 85498..86157(+) (cclA/cilC) [Streptococcus pneumoniae strain M16808]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=304590 DV119_RS00505 WP_000565001.1 85498..86157(+) (cclA/cilC) [Streptococcus pneumoniae strain M16808]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M7B9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

98.174

100

0.982
  cclA/cilC Streptococcus pneumoniae Rx1

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae D39

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae R6

96.804

100

0.968
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

87.215

100

0.872

Multiple sequence alignment