Detailed information NTG0301006

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ETT71_RS06015
• Genome accession: NZ_CP035428
• Coordinates: 1169480..1171723 (-)
• Length: 747 a.a.
• NCBI ID: WP_136106902.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emmSTG866.1
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1164480..1176723

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT71_RS05985 (ETT71_05980)	-	1165132..1166352 (+)	1221	WP_136269979.1	DUF3114 domain-containing protein	-
ETT71_RS05990 (ETT71_05985)	-	1166466..1167288 (-)	823	Protein_1111	serine hydrolase	-
ETT71_RS06000 (ETT71_05995)	-	1167273..1167500 (-)	228	WP_011054657.1	hypothetical protein	-
ETT71_RS06005 (ETT71_06000)	sodA	1167667..1168272 (-)	606	WP_023612500.1	superoxide dismutase SodA	-
ETT71_RS06010 (ETT71_06005)	holA	1168369..1169409 (-)	1041	WP_136269978.1	DNA polymerase III subunit delta	-
ETT71_RS06015 (ETT71_06010)	comEC/celB	1169480..1171723 (-)	2244	WP_136106902.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ETT71_RS06020 (ETT71_06015)	-	1171704..1172366 (-)	663	WP_002983967.1	ComEA family DNA-binding protein	-
ETT71_RS06025 (ETT71_06020)	-	1172566..1173306 (-)	741	WP_002989170.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
ETT71_RS06030 (ETT71_06025)	-	1173424..1174200 (+)	777	WP_010922438.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
ETT71_RS06035 (ETT71_06030)	-	1174190..1174468 (+)	279	WP_002989164.1	GIY-YIG nuclease family protein	-
ETT71_RS06040 (ETT71_06035)	-	1174492..1176480 (-)	1989	WP_136288913.1	potassium transporter Kup	-

Sequence

Protein

• Length: 747 a.a.
• Molecular weight: 85515.45 Da
• Isoelectric Point: 9.7059

>NTDB_id=301006 ETT71_RS06015 WP_136106902.1 1169480..1171723(-) (comEC/celB) [Streptococcus pyogenes strain emmSTG866.1]
MTFSWTKLVPLSKIQFAFLILVLFYQIHSPSWLTFLLSLSLICLLVKRLSKKEFLGVFAILSFCALFLLYQKQQLIQKLE
IQPVQITSVALVPDSIRINGDQLAVLGRHGKHSYQLFYRLKSQAEAQLFKKEHRWLVMHAKVTLEKAEEVRNFKGFNYQT
FLAYQGIYRIGKVEQIEQLEVISPESICDYLSSLRRRAIVHCQQHFPRPMSHYLTGLLFGYLDKSFGEMTDYYSQLGIIH
LFALSGMQVGFFLTCFRRVLLLLAVPLEWIKWIELPFACFYAALTGYSISVIRSLVQSQLRHLGIKGLDNLACTFLLVFL
WDAHFLMTVGGVLTFSYAFLLTVVTVEELSGAKRQLVQVLTISLGILPFLLFYFSSFNPMSMVLTALLSYLFDLFILPLL
CLVFCLSPLVTVSICNHLFILLEKVIQFLGNTFNSSLVFGSPTSWHLLILVISFAIFYDYRQVRQRVITCGLVIALTLLS
VKYPLTNEVTFIDIGQGDSILVREWTGKNLLIDVGGRPFFSSKEHWRRGHHVANAQKTLIPYLKSRGIHTIDQLLVTHAD
TDHMGDIEVVAKAIRIKEILTSQGSLSHPSFVRRLRRLKCHVRVLAAGDQLPIMGSVLQVLYPWQLGDGKNNDSLVLYGR
LLNRTFLFTGDLEKEGENEIIKRYPKLRVDYLKAGHHGSNTSSSAAFLDHIQPKVAFISAGKNNRYQHPHRETLARLEDR
QITYYRTDTQGAIRLTGWTSWHLETVR

Nucleotide

• Length: 2244 bp

>NTDB_id=301006 ETT71_RS06015 WP_136106902.1 1169480..1171723(-) (comEC/celB) [Streptococcus pyogenes strain emmSTG866.1]
ATGACATTTTCTTGGACTAAGCTAGTGCCCCTGTCAAAGATTCAATTTGCTTTTTTAATCTTGGTTCTCTTTTATCAAAT
CCATAGCCCTAGCTGGTTAACGTTTCTCCTTAGCCTTAGTTTGATTTGCTTACTTGTCAAGCGTTTGTCTAAAAAAGAAT
TTCTCGGTGTCTTTGCCATCCTTAGTTTCTGTGCTTTGTTTTTGCTGTATCAGAAACAGCAGTTGATTCAAAAACTGGAA
ATTCAGCCAGTACAAATAACCTCTGTAGCATTAGTTCCTGATAGTATTCGGATTAATGGTGATCAATTAGCTGTTCTTGG
ACGTCACGGGAAACATTCTTATCAGTTATTTTACCGTTTGAAAAGCCAAGCAGAAGCCCAATTGTTCAAGAAAGAGCACC
GTTGGTTAGTGATGCACGCAAAAGTGACATTGGAAAAAGCTGAGGAAGTTCGAAATTTTAAAGGCTTTAATTATCAGACT
TTTTTGGCTTATCAAGGAATTTACAGGATAGGGAAGGTAGAGCAAATAGAACAGCTTGAAGTGATTTCACCCGAGTCAAT
ATGTGACTATTTGTCCTCTTTAAGACGACGAGCCATTGTTCATTGCCAGCAGCATTTTCCAAGACCTATGTCTCACTACC
TGACGGGCCTCCTTTTTGGTTATTTAGATAAGTCGTTTGGTGAGATGACAGATTATTATAGTCAGTTGGGTATCATTCAT
CTCTTTGCTTTATCAGGGATGCAGGTTGGCTTCTTTCTCACTTGTTTTAGAAGGGTGTTGCTATTACTCGCAGTTCCTTT
GGAATGGATAAAATGGATAGAGCTTCCTTTTGCTTGCTTTTATGCCGCGTTGACAGGTTATAGTATTTCTGTTATTCGAA
GCCTCGTGCAGTCGCAGTTGCGTCATTTAGGAATAAAAGGATTAGACAATCTGGCTTGTACTTTTTTACTTGTCTTTTTA
TGGGATGCTCATTTCTTAATGACTGTTGGTGGCGTATTAACGTTTAGCTATGCTTTTTTGTTAACAGTGGTTACTGTTGA
AGAATTATCAGGAGCTAAAAGACAGTTGGTACAAGTCTTGACCATTTCCCTAGGAATATTACCATTTTTGCTCTTTTATT
TTTCTAGTTTTAACCCAATGTCAATGGTCTTAACAGCTCTCTTGTCTTATCTCTTTGACCTTTTTATTTTGCCCCTTCTT
TGTCTGGTTTTTTGTCTATCCCCTTTGGTGACTGTCTCAATATGCAACCATCTTTTTATTTTATTAGAAAAAGTCATTCA
ATTTCTCGGAAATACTTTCAATAGTTCCCTTGTTTTTGGAAGCCCGACCAGTTGGCACTTGCTTATCTTGGTGATTAGCT
TCGCTATTTTTTATGATTATCGGCAGGTGCGACAACGAGTTATCACTTGCGGTTTGGTTATAGCGTTGACGCTTTTGTCT
GTCAAATATCCTTTGACCAATGAAGTGACCTTTATCGACATTGGCCAGGGAGATAGTATTTTGGTGAGGGAGTGGACAGG
GAAAAATCTCTTAATAGATGTAGGTGGGCGCCCTTTCTTTTCTTCAAAAGAGCACTGGCGACGAGGACATCACGTAGCTA
ATGCTCAGAAAACCTTAATTCCTTACTTAAAAAGTAGAGGTATTCACACAATTGACCAACTATTAGTAACTCACGCAGAT
ACTGATCATATGGGGGATATCGAAGTGGTTGCCAAAGCTATTCGGATAAAGGAGATTTTGACTAGTCAAGGCAGTTTAAG
CCATCCAAGCTTTGTTAGGCGGCTAAGGCGTTTAAAATGTCACGTTAGGGTTTTAGCAGCTGGAGACCAGTTGCCTATTA
TGGGAAGTGTCTTACAGGTACTCTACCCTTGGCAGTTAGGGGACGGGAAAAATAACGATTCTTTGGTACTTTATGGCAGG
CTCTTAAATCGAACTTTTCTTTTCACAGGTGACTTGGAAAAAGAGGGGGAAAACGAGATCATAAAACGTTATCCTAAACT
AAGAGTAGATTATTTAAAAGCAGGTCACCATGGATCAAATACCTCTTCTAGTGCGGCTTTTTTAGACCATATTCAACCTA
AAGTGGCCTTTATTTCTGCTGGAAAAAATAACCGTTATCAGCATCCTCACAGAGAAACCTTAGCCCGTTTGGAAGACAGA
CAAATTACTTATTACCGAACGGATACGCAAGGAGCTATTCGTTTGACTGGTTGGACAAGCTGGCATCTTGAAACGGTCCG
TTAG

Domains

Predicted by InterProScan.

• Competence protein (Competence) (217-462)

• Metallo-beta-lactamase superfamily (Lactamase_B) (495-701)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	46.319	100	0.463
comEC/celB	Streptococcus mitis NCTC 12261	46.113	99.866	0.461
comEC/celB	Streptococcus pneumoniae TIGR4	45.114	100	0.451
comEC/celB	Streptococcus pneumoniae Rx1	44.92	100	0.45
comEC/celB	Streptococcus pneumoniae D39	44.92	100	0.45
comEC/celB	Streptococcus pneumoniae R6	44.92	100	0.45
comEC	Lactococcus lactis subsp. cremoris KW2	40.805	99.732	0.407