Detailed information NTG0030049

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: SPH_RS11115
• Genome accession: NC_010380
• Coordinates: 2076334..2077041 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166476.1
• Uniprot ID: B1I9F0
• Organism: Streptococcus pneumoniae Hungary19A-6
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2075222..2075611	2076334..2077041	flank	723

Gene organization within MGE regions

Location: 2075222..2077041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPH_RS11105 (SPH_2267)	-	2075222..2075779 (-)	558	Protein_2082	transposase family protein	-
SPH_RS11110 (SPH_2268)	-	2075765..2076250 (+)	486	WP_001815029.1	cupin domain-containing protein	-
SPH_RS11115 (SPH_2269)	vicR	2076334..2077041 (+)	708	WP_000166476.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27278.70 Da
• Isoelectric Point: 6.9852

>NTDB_id=30049 SPH_RS11115 WP_000166476.1 2076334..2077041(+) (vicR) [Streptococcus pneumoniae Hungary19A-6]
MTKQVLLVDDEEHILKLLYYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=30049 SPH_RS11115 WP_000166476.1 2076334..2077041(+) (vicR) [Streptococcus pneumoniae Hungary19A-6]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTTACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTTACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATGGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

• Response regulator receiver domain (Response_reg) (5-115)

3D structure

• AlphaFold DB: B1I9F0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	40.773	99.149	0.404
covR	Streptococcus salivarius strain HSISS4	39.744	99.574	0.396