Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SUB_RS02595 Genome accession   NC_012004
Coordinates   477357..478097 (+) Length   246 a.a.
NCBI ID   WP_012658029.1    Uniprot ID   A9Q0N5
Organism   Streptococcus uberis 0140J     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 472357..483097
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SUB_RS02565 (SUB0491) - 472762..473166 (+) 405 WP_012658023.1 diacylglycerol kinase family protein -
  SUB_RS02570 (SUB0492) era 473188..474087 (+) 900 WP_012658024.1 GTPase Era -
  SUB_RS02575 (SUB0494) - 474461..474847 (+) 387 WP_012658025.1 hypothetical protein -
  SUB_RS02580 (SUB0495) - 474906..475697 (+) 792 WP_012658026.1 hypothetical protein -
  SUB_RS02590 (SUB0497) - 476300..476929 (+) 630 WP_012658028.1 ATP-binding cassette domain-containing protein -
  SUB_RS09805 - 476975..477114 (+) 140 Protein_477 DNA mismatch repair protein MutT -
  SUB_RS02595 (SUB0498) comE/blpR 477357..478097 (+) 741 WP_012658029.1 LytR/AlgR family response regulator transcription factor Regulator
  SUB_RS02600 (SUB0499) comD/blpH 478624..479439 (+) 816 WP_170123120.1 sensor histidine kinase Regulator
  SUB_RS09810 - 479449..479595 (-) 147 WP_080502297.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SUB_RS02605 (SUB0501) comA/nlmT 479631..481784 (-) 2154 WP_012658032.1 peptide cleavage/export ABC transporter Regulator
  SUB_RS02610 (SUB0502) - 482015..482248 (+) 234 Protein_482 ComC/BlpC family peptide pheromone/bacteriocin -
  SUB_RS02615 (SUB0505) - 482867..483091 (+) 225 WP_046388584.1 Blp family class II bacteriocin -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 29126.83 Da        Isoelectric Point: 9.9344

>NTDB_id=29654 SUB_RS02595 WP_012658029.1 477357..478097(+) (comE/blpR) [Streptococcus uberis 0140J]
MNIYILEDNLSQLFYLEKLIKQILLQKNRQNCKVKTFEQPKDLINNVKERGNHQLFFLDIELGQNDKLGLLTAKKIKELD
PLAIIVFISSHSEFLPLTFRYQTEAFDFIDKNLCTKEKIERITRAINFVINNSHSMKTSFFFENQNNILQIPFEKIFFIE
TSSESHRLILHGKNEIIEFYGSISEVLKQEPRLLKSHRSYIINPNNVVKIDKKERTIYFERGIKCYASRSKLKFITNSIS
NIRKEK

Nucleotide


Download         Length: 741 bp        

>NTDB_id=29654 SUB_RS02595 WP_012658029.1 477357..478097(+) (comE/blpR) [Streptococcus uberis 0140J]
GTGAATATTTATATACTGGAAGACAATTTAAGTCAGCTATTCTACCTTGAAAAATTGATAAAACAAATACTTTTACAAAA
AAATAGGCAAAATTGTAAAGTTAAAACTTTTGAACAACCGAAGGATTTAATAAATAATGTGAAAGAAAGAGGAAATCATC
AATTATTTTTTCTTGATATTGAATTAGGTCAAAATGATAAGTTAGGGCTATTAACTGCAAAAAAGATTAAAGAACTTGAC
CCTTTAGCAATTATAGTATTTATTTCAAGCCACTCAGAGTTTTTGCCTTTAACTTTTAGATATCAAACGGAAGCCTTTGA
TTTTATTGATAAAAACCTATGCACGAAAGAAAAAATTGAAAGAATAACAAGAGCAATAAATTTTGTTATTAACAATAGTC
ATTCAATGAAGACTTCATTCTTTTTTGAAAATCAAAATAACATCCTGCAAATTCCTTTTGAAAAAATATTTTTTATTGAA
ACTTCGTCAGAATCACATCGACTTATCTTGCACGGGAAAAATGAAATTATTGAATTTTATGGAAGTATTTCTGAGGTATT
AAAACAAGAACCAAGACTATTAAAATCTCATCGTTCTTATATAATCAACCCAAATAATGTGGTCAAAATTGATAAAAAAG
AACGAACTATTTATTTTGAAAGAGGGATAAAGTGTTATGCTTCCCGTTCAAAATTAAAGTTTATTACAAATAGTATCAGT
AACATAAGAAAGGAGAAATGA

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(147-235)

Response regulator receiver domain (Response_reg)

(4-119)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A9Q0N5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

41.767

100

0.423
  comE/comE1 Streptococcus equinus JB1

41.393

99.187

0.411
  comE/comE2 Streptococcus equinus JB1

38.211

100

0.382

Multiple sequence alignment