Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   DMC16_RS10675 Genome accession   NZ_CP029686
Coordinates   2049608..2051800 (+) Length   730 a.a.
NCBI ID   WP_003567347.1    Uniprot ID   A0A826HY20
Organism   Lacticaseibacillus paracasei strain Lpc10     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2044608..2056800
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DMC16_RS10640 (DMC16_10635) - 2044705..2044893 (+) 189 WP_003567358.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  DMC16_RS10645 (DMC16_10640) - 2044928..2045101 (+) 174 WP_032675994.1 bacteriocin -
  DMC16_RS10650 (DMC16_10645) - 2045361..2045600 (-) 240 WP_003567354.1 hypothetical protein -
  DMC16_RS10655 (DMC16_10650) - 2046147..2046344 (+) 198 WP_003659579.1 hypothetical protein -
  DMC16_RS10660 (DMC16_10655) - 2046706..2047512 (-) 807 WP_003567351.1 LytTR family DNA-binding domain-containing protein -
  DMC16_RS10665 (DMC16_10660) - 2047517..2048815 (-) 1299 WP_003567349.1 GHKL domain-containing protein -
  DMC16_RS10670 (DMC16_10665) - 2049005..2049142 (+) 138 WP_003571414.1 bacteriocin-like peptide, LSEI_2386 family -
  DMC16_RS10675 (DMC16_10670) comA 2049608..2051800 (+) 2193 WP_003567347.1 peptide cleavage/export ABC transporter Regulator
  DMC16_RS10680 (DMC16_10675) - 2051811..2053190 (+) 1380 WP_003567343.1 bacteriocin secretion accessory protein -
  DMC16_RS10685 (DMC16_10680) - 2053364..2053714 (+) 351 WP_003567340.1 hypothetical protein -
  DMC16_RS10690 (DMC16_10685) - 2053787..2054098 (+) 312 WP_003580849.1 hypothetical protein -
  DMC16_RS10695 (DMC16_10690) - 2054404..2055759 (+) 1356 WP_003567335.1 threonine/serine exporter ThrE family protein -
  DMC16_RS10700 (DMC16_10695) - 2055861..2056157 (+) 297 WP_003567333.1 bacteriocin immunity protein -
  DMC16_RS10705 (DMC16_10700) - 2056349..2056633 (+) 285 WP_003567331.1 bacteriocin immunity protein -

Sequence

Protein


Download         Length: 730 a.a.        Molecular weight: 81262.49 Da        Isoelectric Point: 7.2447

>NTDB_id=295306 DMC16_RS10675 WP_003567347.1 2049608..2051800(+) (comA) [Lacticaseibacillus paracasei strain Lpc10]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPANAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHTELLAK
QGYYARLVSE

Nucleotide


Download         Length: 2193 bp        

>NTDB_id=295306 DMC16_RS10675 WP_003567347.1 2049608..2051800(+) (comA) [Lacticaseibacillus paracasei strain Lpc10]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAACGTTTGTCGATTGATGTCATTTTGGGTTACGTCAGACACCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGCACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCTATTATCGAGGACTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGCGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGTGTTCCCATC
AGTGATGTTGATCTAACAACGTTACGCCAATACATCGAGTATGTACCGCAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATACTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(16-152)

ABC transporter (ABC_tran)

(510-662)

ABC transporter transmembrane region (ABC_membrane)

(180-448)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A826HY20

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

58.635

98.356

0.577
  comA Streptococcus pneumoniae Rx1

58.078

98.356

0.571
  comA Streptococcus pneumoniae D39

58.078

98.356

0.571
  comA Streptococcus pneumoniae R6

58.078

98.356

0.571
  comA Streptococcus mitis SK321

57.939

98.356

0.57
  comA Streptococcus pneumoniae TIGR4

57.66

98.356

0.567
  comA Streptococcus gordonii str. Challis substr. CH1

57.103

98.356

0.562
  comA/nlmT Streptococcus mutans UA159

54.848

98.904

0.542

Multiple sequence alignment