Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DK182_RS06350 Genome accession   NZ_CP029491
Coordinates   1275066..1275740 (-) Length   224 a.a.
NCBI ID   WP_002961524.1    Uniprot ID   U2KC16
Organism   Streptococcus sobrinus strain 10919     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1270066..1280740
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK182_RS06325 (DK181_06325) - 1270426..1271703 (-) 1278 WP_002963359.1 pyrimidine-nucleoside phosphorylase -
  DK182_RS06330 (DK181_06330) - 1271700..1272290 (-) 591 WP_019777495.1 class I SAM-dependent methyltransferase -
  DK182_RS06335 (DK181_06335) coaA 1272355..1273275 (+) 921 WP_019777496.1 type I pantothenate kinase -
  DK182_RS06340 (DK181_06340) rpsT 1273328..1273576 (+) 249 WP_019772096.1 30S ribosomal protein S20 -
  DK182_RS06345 (DK181_06345) ciaH 1273691..1275076 (-) 1386 WP_002961522.1 sensor histidine kinase Regulator
  DK182_RS06350 (DK181_06350) ciaR 1275066..1275740 (-) 675 WP_002961524.1 response regulator transcription factor Regulator
  DK182_RS06355 (DK181_06355) - 1276005..1278548 (-) 2544 WP_019790734.1 M1 family metallopeptidase -
  DK182_RS06360 (DK181_06360) phoU 1278655..1279308 (-) 654 WP_002961527.1 phosphate signaling complex protein PhoU -
  DK182_RS06365 (DK181_06365) pstB 1279348..1280106 (-) 759 WP_019775440.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25369.21 Da        Isoelectric Point: 4.3647

>NTDB_id=293219 DK182_RS06350 WP_002961524.1 1275066..1275740(-) (ciaR) [Streptococcus sobrinus strain 10919]
MIKILLVEDDLSLSNSVYDFLDDFAEVTQVFDGEEGLFEAETGVYDLILLDLMLPEKDGFTVLKELRDKGVATPVLITTA
KEALDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKINDKLLTYGDLECDTSTNTVTVNGKIVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTVSVVEVYVSKIRKKLKGTDFEKCLQTLRSVGYILKDVK

Nucleotide


Download         Length: 675 bp        

>NTDB_id=293219 DK182_RS06350 WP_002961524.1 1275066..1275740(-) (ciaR) [Streptococcus sobrinus strain 10919]
ATGATTAAAATTTTATTAGTAGAAGATGATTTAAGTCTTTCAAATTCCGTCTATGATTTTCTAGATGACTTTGCTGAAGT
TACCCAAGTCTTTGATGGAGAAGAAGGCCTATTTGAAGCAGAAACTGGTGTTTATGACTTGATTCTGCTTGATTTGATGT
TGCCAGAAAAAGATGGTTTCACCGTTCTTAAGGAATTACGTGATAAGGGTGTTGCAACCCCTGTTTTGATTACAACCGCC
AAAGAAGCACTTGATGATAAAGGACATGGTTTTGAACTGGGTGCCGATGATTATCTGACCAAGCCTTTCTACTTGGAAGA
ATTAAAGATGCGGATTCAGGCCCTTTTGAAGCGTTCAGGTAAAATCAATGATAAGTTGCTGACCTATGGCGATTTAGAAT
GTGATACCTCCACTAATACCGTTACTGTAAATGGTAAGATTGTCGAATTGTTGGGTAAGGAATTTGACCTCTTGGTTTAT
TTCTTGCAAAATCAAAATGTTATCTTACCTAAGACACAAATTTTTGATAGAATTTGGGGCTTTGATAGTGATACAACAGT
TTCTGTTGTTGAGGTCTATGTTTCTAAGATTCGTAAAAAATTAAAGGGAACGGATTTCGAAAAATGTCTACAAACACTGC
GCAGTGTGGGGTATATTCTAAAGGATGTTAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(148-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2KC16

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.268

100

0.853
  ciaR Streptococcus pneumoniae Rx1

83.482

100

0.835
  ciaR Streptococcus pneumoniae D39

83.482

100

0.835
  ciaR Streptococcus pneumoniae R6

83.482

100

0.835
  ciaR Streptococcus pneumoniae TIGR4

83.482

100

0.835
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.004

100

0.375

Multiple sequence alignment