Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   C7K40_RS07940 Genome accession   NZ_CP027771
Coordinates   1565515..1566201 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain DMG1800716     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1560515..1571201
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C7K40_RS07920 (C7K40_07915) dnaI 1561236..1562138 (-) 903 WP_015016699.1 primosomal protein DnaI -
  C7K40_RS07925 (C7K40_07920) - 1562139..1563314 (-) 1176 WP_009880401.1 replication initiation and membrane attachment family protein -
  C7K40_RS07930 (C7K40_07925) nrdR 1563298..1563792 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  C7K40_RS07935 (C7K40_07930) covS 1564007..1565509 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  C7K40_RS07940 (C7K40_07935) covR 1565515..1566201 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  C7K40_RS07945 (C7K40_07940) - 1566468..1567001 (-) 534 WP_032464180.1 DUF177 domain-containing protein -
  C7K40_RS07950 (C7K40_07945) htpX 1567235..1568131 (-) 897 WP_023613085.1 zinc metalloprotease HtpX -
  C7K40_RS07955 (C7K40_07950) - 1568178..1568735 (-) 558 WP_002985956.1 LemA family protein -
  C7K40_RS07960 (C7K40_07955) rsmG 1568885..1569598 (+) 714 WP_023613076.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  C7K40_RS07965 (C7K40_07960) ktrB 1569682..1571058 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=280465 C7K40_RS07940 WP_002991052.1 1565515..1566201(-) (covR) [Streptococcus pyogenes strain DMG1800716]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=280465 C7K40_RS07940 WP_002991052.1 1565515..1566201(-) (covR) [Streptococcus pyogenes strain DMG1800716]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTACTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment