Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SPYM_RS07895 Genome accession   NC_009332
Coordinates   1547699..1548385 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes str. Manfredo     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1542699..1553385
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYM_RS07875 (SpyM51569) dnaI 1543420..1544322 (-) 903 WP_002991016.1 primosomal protein DnaI -
  SPYM_RS07880 (SpyM51570) - 1544323..1545498 (-) 1176 WP_030127140.1 replication initiation and membrane attachment family protein -
  SPYM_RS07885 (SpyM51571) nrdR 1545482..1545976 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  SPYM_RS07890 (SpyM51572) covS 1546191..1547693 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  SPYM_RS07895 (SpyM51573) covR 1547699..1548385 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  SPYM_RS07900 (SpyM51574) - 1548652..1549185 (-) 534 WP_011889133.1 YceD family protein -
  SPYM_RS07905 (SpyM51575) htpX 1549419..1550315 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  SPYM_RS07910 (SpyM51576) - 1550362..1550919 (-) 558 WP_011889134.1 LemA family protein -
  SPYM_RS07915 (SpyM51577) rsmG 1551069..1551782 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  SPYM_RS07920 (SpyM51578) ktrB 1551867..1553243 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=27875 SPYM_RS07895 WP_002991052.1 1547699..1548385(-) (covR) [Streptococcus pyogenes str. Manfredo]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=27875 SPYM_RS07895 WP_002991052.1 1547699..1548385(-) (covR) [Streptococcus pyogenes str. Manfredo]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGGAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment