Detailed information NTG0271476

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: C4N11_RS11685
• Genome accession: NZ_CP026670
• Coordinates: 2188135..2188797 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649974.1
• Uniprot ID: A0A0F7YBW3
• Organism: Streptococcus pneumoniae strain endophthalmitis isolate 335
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2183135..2193797

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C4N11_RS11660 (C4N11_11660)	-	2183285..2183551 (-)	267	WP_001278167.1	Veg family protein	-
C4N11_RS11665 (C4N11_11665)	dnaB	2183553..2184905 (-)	1353	WP_000852486.1	replicative DNA helicase	-
C4N11_RS11670 (C4N11_11670)	rplI	2184949..2185401 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
C4N11_RS11675 (C4N11_11675)	-	2185398..2187371 (-)	1974	WP_000715123.1	DHH family phosphoesterase	-
C4N11_RS11680 (C4N11_11680)	raiA	2187507..2188055 (-)	549	WP_000599107.1	ribosome-associated translation inhibitor RaiA	-
C4N11_RS11685 (C4N11_11685)	comFC/cflB	2188135..2188797 (-)	663	WP_000649974.1	ComF family protein	Machinery gene
C4N11_RS11690 (C4N11_11690)	comFA/cflA	2188794..2190092 (-)	1299	WP_000867608.1	DEAD/DEAH box helicase	Machinery gene
C4N11_RS11695 (C4N11_11695)	-	2190148..2190783 (+)	636	WP_000395739.1	YigZ family protein	-
C4N11_RS11700 (C4N11_11700)	cysK	2191068..2191988 (+)	921	WP_000029866.1	cysteine synthase A	-
C4N11_RS11710 (C4N11_11710)	-	2192063..2192592 (-)	530	Protein_2168	transposase	-
C4N11_RS11715 (C4N11_11715)	-	2192574..2192882 (+)	309	Protein_2169	transposase	-
C4N11_RS11720 (C4N11_11720)	tnpB	2193037..2193360 (-)	324	WP_000973408.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25169.03 Da
• Isoelectric Point: 7.7116

>NTDB_id=271476 C4N11_RS11685 WP_000649974.1 2188135..2188797(-) (comFC/cflB) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQLWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=271476 C4N11_RS11685 WP_000649974.1 2188135..2188797(-) (comFC/cflB) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAACTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A0F7YBW3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	100	100	1
comFC/cflB	Streptococcus pneumoniae D39	100	100	1
comFC/cflB	Streptococcus pneumoniae R6	100	100	1
comFC/cflB	Streptococcus pneumoniae TIGR4	99.545	100	0.995
comFC/cflB	Streptococcus mitis NCTC 12261	91.364	100	0.914
comFC/cflB	Streptococcus mitis SK321	90.909	100	0.909