Detailed information NTG0026707

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPD_RS09400
• Genome accession: NC_008533
• Coordinates: 1764048..1765085 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae D39
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1759048..1770085

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPD_RS09375 (SPD_1761)	-	1759849..1761180 (-)	1332	WP_000390046.1	hemolysin family protein	-
SPD_RS09380 (SPD_1762)	endA	1761409..1762233 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
SPD_RS09385 (SPD_1763)	-	1762272..1762460 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SPD_RS09390 (SPD_1764)	murA	1762453..1763736 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPD_RS09395	-	1763760..1763990 (-)	231	WP_000250384.1	DUF1146 family protein	-
SPD_RS09400 (SPD_1765)	sepM	1764048..1765085 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SPD_RS09405 (SPD_1766)	coaD	1765069..1765557 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
SPD_RS09410 (SPD_1767)	rsmD	1765547..1766086 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPD_RS09415 (SPD_1768)	asnA	1766151..1767143 (-)	993	WP_000747995.1	aspartate--ammonia ligase	-
SPD_RS09425 (SPD_1769)	-	1767255..1767938 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SPD_RS09430 (SPD_1771)	-	1767994..1768734 (-)	741	WP_000152673.1	TrmH family RNA methyltransferase	-
SPD_RS09435 (SPD_1772)	-	1768768..1769046 (+)	279	WP_001174613.1	acylphosphatase	-
SPD_RS09440 (SPD_1773)	yidC	1769124..1770050 (+)	927	WP_000835947.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=26707 SPD_RS09400 WP_000727277.1 1764048..1765085(-) (sepM) [Streptococcus pneumoniae D39]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=26707 SPD_RS09400 WP_000727277.1 1764048..1765085(-) (sepM) [Streptococcus pneumoniae D39]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591