Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   C2E46_RS04365 Genome accession   NZ_CP026082
Coordinates   836351..838588 (+) Length   745 a.a.
NCBI ID   WP_000939913.1    Uniprot ID   A0A0H1YD12
Organism   Streptococcus agalactiae strain YZ1605     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 831351..843588
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C2E46_RS04340 (C2E46_04460) - 831949..833535 (+) 1587 WP_161501832.1 DEAD/DEAH box helicase -
  C2E46_RS04345 (C2E46_04465) - 833717..833983 (-) 267 WP_000598734.1 GIY-YIG nuclease family protein -
  C2E46_RS04350 (C2E46_04470) - 833976..834740 (-) 765 WP_000611115.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  C2E46_RS04355 (C2E46_04475) - 834875..835615 (+) 741 WP_000500220.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  C2E46_RS04360 (C2E46_04480) - 835714..836367 (+) 654 WP_161501833.1 helix-hairpin-helix domain-containing protein -
  C2E46_RS04365 (C2E46_04485) comEC/celB 836351..838588 (+) 2238 WP_000939913.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  C2E46_RS04370 (C2E46_04490) - 838714..839523 (+) 810 WP_000153219.1 Cof-type HAD-IIB family hydrolase -
  C2E46_RS04375 (C2E46_04495) - 839534..840478 (+) 945 WP_000200832.1 LacI family DNA-binding transcriptional regulator -
  C2E46_RS04380 (C2E46_04500) - 840537..841529 (-) 993 WP_000800992.1 alpha/beta hydrolase fold domain-containing protein -
  C2E46_RS04385 (C2E46_04505) - 841705..842433 (+) 729 WP_000468971.1 methyltransferase domain-containing protein -
  C2E46_RS04390 (C2E46_04510) holA 842487..843524 (+) 1038 WP_000560292.1 DNA polymerase III subunit delta -

Sequence

Protein


Download         Length: 745 a.a.        Molecular weight: 85445.26 Da        Isoelectric Point: 9.7374

>NTDB_id=266900 C2E46_RS04365 WP_000939913.1 836351..838588(+) (comEC/celB) [Streptococcus agalactiae strain YZ1605]
MLQLTKYFPLKPIYLALLVFQIYLLVFSWTMLGCAFLLFTFIFLIYQYDRETIFKTIAIVIFFLFYFLWQNHNMNVQYQR
VPNHISQIEVRIDTISINGDVLSFQADASGNTYQAFYTLKNKSEKDYFQNLDNNIMIIADIKLEEAEERRHFNGFDYRQY
LKRHGIYRIAKVTKIKQIRLSQHRSFFALMSKWRRSAIVISQTFPNPMRHYMSGLLFGYLDKTFDDMSDLYSSLGIIHLF
ALSGMQVGFFLGIFRYICLRIGLRLDHVWLLQIPFSLIYAGLTGFSISVVRALIQSLLSHSGVKKDENFALCLLICLISL
PHSLLTTGGVLSFAYAFILTMTSFDHFSSIKKLAIESLTVSVGILPILTYYFSGFQPISIILTALLSFAFDIIFLPLLTV
IFVLSPIVKLSCINSLFEILEVLLKWTGQLFPRPLIFGKPSLFLLIVMIIILGLLYDYYHSKCFRYCSLLIIFTLFFITK
NPITNEVAILDVGQGDSILVRDWLGKTILIDTGGRVRFEQPEEWKQKVNQSNAERTLIPYLKSRGISKIDDLVITHTDTD
HMGDMEVISKHFKVARLITSSGSLTNSQYVKRLSKIGVAVKSIEAGDKLSVMGSYLQVLYPWHKGDGKNNDSIVLYGHLL
GKGFLFTGDLEEEGEKQLLEAYPNLSVDILKAGHHGSKGSSSLSFLKKLSPSVVLVSAGKNNRYQHPHQETLQRFQKIKS
KIFRTDQSGTIRLTGWWKWHIQTVR

Nucleotide


Download         Length: 2238 bp        

>NTDB_id=266900 C2E46_RS04365 WP_000939913.1 836351..838588(+) (comEC/celB) [Streptococcus agalactiae strain YZ1605]
ATGTTACAATTGACTAAGTATTTTCCTCTAAAACCTATTTATTTAGCATTGTTGGTCTTCCAAATTTACTTACTAGTGTT
TTCTTGGACAATGCTTGGTTGTGCCTTTCTTTTATTTACTTTTATTTTTCTGATTTATCAATATGATCGTGAAACTATTT
TTAAAACAATAGCAATAGTAATTTTTTTCTTATTTTATTTTTTATGGCAAAATCACAATATGAATGTCCAATATCAAAGA
GTACCGAATCATATTAGCCAGATTGAAGTGCGTATTGATACTATTTCTATCAATGGTGATGTTTTATCATTCCAGGCAGA
TGCTTCAGGTAACACTTATCAAGCTTTTTACACATTAAAAAATAAAAGTGAGAAAGATTATTTTCAAAATCTTGATAATA
ATATAATGATCATTGCAGATATCAAACTCGAAGAAGCAGAGGAGAGAAGGCATTTTAATGGCTTTGATTATCGTCAGTAT
TTAAAAAGACATGGAATTTATCGTATCGCCAAAGTGACAAAGATAAAACAGATACGCTTATCTCAACATAGGTCTTTCTT
TGCTCTTATGTCTAAGTGGCGTAGAAGTGCAATTGTTATTAGTCAAACTTTTCCAAATCCTATGCGTCACTATATGTCAG
GGCTTTTGTTTGGATATCTAGATAAGACCTTTGATGACATGTCCGATTTATATAGTAGTCTAGGTATTATACATTTATTT
GCTTTGTCAGGTATGCAAGTAGGTTTTTTTCTCGGTATTTTTCGTTATATCTGTCTACGTATTGGCTTACGCCTAGACCA
TGTTTGGTTACTTCAAATACCATTCTCGCTAATTTATGCTGGTTTAACAGGCTTTAGTATCTCAGTTGTTAGGGCACTTA
TTCAATCTTTATTATCACATAGCGGTGTCAAGAAAGATGAGAACTTTGCTCTCTGCTTGTTAATTTGTCTTATCTCTCTC
CCCCACTCACTTTTGACTACGGGAGGAGTTCTTAGCTTTGCTTATGCTTTTATACTTACGATGACCTCCTTTGATCATTT
TTCGAGTATAAAAAAACTAGCTATCGAATCTTTGACAGTCTCTGTAGGAATTCTTCCCATACTAACCTACTATTTTTCAG
GTTTTCAACCAATATCAATTATATTAACAGCACTTTTATCTTTTGCATTTGATATTATATTTTTGCCTTTATTAACTGTT
ATATTTGTCTTATCGCCTATCGTTAAATTAAGTTGTATTAATAGTTTGTTTGAAATCCTAGAAGTGTTATTAAAATGGAC
TGGGCAACTGTTTCCAAGGCCACTTATTTTTGGAAAGCCCAGCCTTTTTCTTTTAATAGTCATGATTATAATTTTGGGAT
TACTTTATGATTATTATCATTCTAAATGTTTTCGTTATTGCTCCCTTCTTATTATCTTTACCTTGTTTTTTATCACTAAG
AATCCAATTACTAACGAGGTTGCGATTTTAGATGTTGGACAGGGAGATAGTATTTTAGTGAGGGATTGGTTAGGAAAAAC
AATTTTAATTGATACTGGGGGAAGGGTGAGATTTGAACAGCCTGAAGAATGGAAACAAAAAGTAAATCAGTCTAATGCTG
AGAGAACGCTCATTCCTTACTTGAAAAGCAGAGGTATTAGCAAGATAGATGATTTAGTGATAACTCATACCGATACAGAT
CATATGGGGGATATGGAAGTTATCTCAAAGCATTTTAAAGTTGCACGTTTGATTACAAGTTCAGGTTCTTTAACGAATTC
GCAGTACGTTAAGCGTTTATCAAAGATAGGAGTAGCTGTAAAATCTATAGAAGCTGGTGATAAACTTTCTGTCATGGGAA
GTTATTTACAAGTACTTTACCCATGGCACAAGGGTGATGGAAAAAATAATGATTCAATTGTTTTATATGGACATTTATTA
GGAAAAGGTTTCTTATTTACCGGTGATTTGGAGGAAGAGGGAGAAAAGCAGTTATTAGAAGCTTATCCTAATTTATCAGT
AGATATCCTTAAAGCAGGACATCATGGTTCTAAGGGATCATCAAGTCTATCCTTTCTGAAAAAGTTGTCTCCTAGTGTGG
TGCTAGTGTCAGCTGGTAAAAATAATCGTTACCAGCATCCTCATCAAGAGACTTTACAAAGGTTCCAAAAGATTAAAAGC
AAGATTTTCCGAACGGATCAATCAGGTACAATTAGGCTAACAGGATGGTGGAAGTGGCATATTCAGACAGTTCGTTGA

Domains

Predicted by InterproScan.

Competence protein (Competence)

(215-458)

Domain of unknown function (DUF4131) (DUF4131)

(28-177)

Metallo-beta-lactamase superfamily (Lactamase_B)

(491-576)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H1YD12

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus mitis NCTC 12261

48.4

100

0.487
  comEC/celB Streptococcus mitis SK321

48.396

100

0.486
  comEC/celB Streptococcus pneumoniae TIGR4

46.925

100

0.471
  comEC/celB Streptococcus pneumoniae Rx1

46.452

100

0.466
  comEC/celB Streptococcus pneumoniae D39

46.452

100

0.466
  comEC/celB Streptococcus pneumoniae R6

46.452

100

0.466
  comEC Lactococcus lactis subsp. cremoris KW2

43.876

99.732

0.438

Multiple sequence alignment