Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CSC39_RS04585 Genome accession   NZ_CP030331
Coordinates   697859..698518 (-) Length   219 a.a.
NCBI ID   WP_112021718.1    Uniprot ID   -
Organism   Escherichia coli strain AR_452     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 692859..703518
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CSC39_RS04560 (CSC39_0707) parE 692950..694842 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  CSC39_RS04565 (CSC39_0708) ygiN 694890..695204 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CSC39_RS04570 (CSC39_0709) mdaB 695235..695816 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CSC39_RS04575 ygiZ 696135..696467 (+) 333 WP_000912120.1 DUF2645 family protein -
  CSC39_RS04580 (CSC39_0710) qseC 696513..697862 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  CSC39_RS04585 (CSC39_0711) ciaR 697859..698518 (-) 660 WP_112021718.1 quorum sensing response regulator transcription factor QseB Regulator
  CSC39_RS04590 (CSC39_0712) ygiW 698670..699062 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CSC39_RS04595 (CSC39_0713) ygiV 699115..699597 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  CSC39_RS04605 (CSC39_0714) parC 700143..702401 (+) 2259 WP_024249834.1 DNA topoisomerase IV subunit A -
  CSC39_RS04610 (CSC39_0715) plsC 702635..703372 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24759.69 Da        Isoelectric Point: 6.6546

>NTDB_id=259959 CSC39_RS04585 WP_112021718.1 697859..698518(-) (ciaR) [Escherichia coli strain AR_452]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSEFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=259959 CSC39_RS04585 WP_112021718.1 697859..698518(-) (ciaR) [Escherichia coli strain AR_452]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGAGTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365
  micA Streptococcus pneumoniae Cp1015

34.498

100

0.361

Multiple sequence alignment