Detailed information NTG0259508

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: CXP32_RS11590
• Genome accession: NZ_CP025256
• Coordinates: 2165470..2165595 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain Xen35
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2160470..2170595

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CXP32_RS12510	-	2160809..2162411 (-)	1603	Protein_2129	YhgE/Pip domain-containing protein	-
CXP32_RS11565 (CXP32_11565)	-	2162590..2163132 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
CXP32_RS11580 (CXP32_11580)	comE	2163375..2164127 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
CXP32_RS11585 (CXP32_11585)	comD/comD2	2164124..2165449 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
CXP32_RS11590 (CXP32_11590)	comC/comC2	2165470..2165595 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
CXP32_RS11600 (CXP32_11600)	rlmH	2165877..2166356 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
CXP32_RS11605 (CXP32_11605)	htrA	2166539..2167720 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
CXP32_RS11610 (CXP32_11610)	spo0J	2167778..2168536 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=259508 CXP32_RS11590 WP_000799686.1 2165470..2165595(-) (comC/comC2) [Streptococcus pneumoniae strain Xen35]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=259508 CXP32_RS11590 WP_000799686.1 2165470..2165595(-) (comC/comC2) [Streptococcus pneumoniae strain Xen35]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561