Detailed information NTG0259447

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: CXP32_RS02640
• Genome accession: NZ_CP025256
• Coordinates: 505559..506296 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain Xen35
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 500559..511296

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CXP32_RS02605 (CXP32_02605)	-	501891..502178 (-)	288	WP_000777760.1	hypothetical protein	-
CXP32_RS02610 (CXP32_02610)	-	502188..502598 (-)	411	WP_001278301.1	HIT family protein	-
CXP32_RS02615 (CXP32_02615)	pptA	502666..503397 (+)	732	WP_000889924.1	ABC transporter ATP-binding protein	Regulator
CXP32_RS02620 (CXP32_02620)	-	503394..504443 (+)	1050	WP_000653779.1	ABC transporter permease	-
CXP32_RS02630 (CXP32_02630)	-	504611..504940 (-)	330	WP_000132572.1	hypothetical protein	-
CXP32_RS02635 (CXP32_02635)	-	505216..505554 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
CXP32_RS02640 (CXP32_02640)	comE/blpR	505559..506296 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
CXP32_RS02645 (CXP32_02645)	-	506310..507650 (+)	1341	WP_001017646.1	sensor histidine kinase	-
CXP32_RS02650 (CXP32_02650)	blpC	507721..507849 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
CXP32_RS02655 (CXP32_02655)	-	507906..509267 (-)	1362	WP_001069075.1	bacteriocin secretion accessory protein	-
CXP32_RS12660 (CXP32_02660)	comA/nlmT	509278..509925 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
CXP32_RS12665 (CXP32_02665)	comA/nlmT	509941..510954 (-)	1014	WP_307772067.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=259447 CXP32_RS02640 WP_001219120.1 505559..506296(+) (comE/blpR) [Streptococcus pneumoniae strain Xen35]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=259447 CXP32_RS02640 WP_001219120.1 505559..506296(+) (comE/blpR) [Streptococcus pneumoniae strain Xen35]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363