Detailed information NTG0249808

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: CRD75_RS00325
• Genome accession: NZ_CP023769
• Coordinates: 52557..53468 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain HarveyGAS
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47557..58468

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CRD75_RS00305 (CRD75_00305)	purE	48143..48634 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CRD75_RS00310 (CRD75_00310)	purK	48621..49694 (+)	1074	WP_021340856.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CRD75_RS00315 (CRD75_00315)	-	49696..51114 (+)	1419	WP_011888524.1	hypothetical protein	-
CRD75_RS00320 (CRD75_00320)	purB	51134..52426 (+)	1293	WP_011284409.1	adenylosuccinate lyase	-
CRD75_RS00325 (CRD75_00325)	comR	52557..53468 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
CRD75_RS09745	comS	53552..53647 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
CRD75_RS00330 (CRD75_00330)	ruvB	53694..54692 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
CRD75_RS00335 (CRD75_00335)	-	54830..55267 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
CRD75_RS00340 (CRD75_00340)	-	55290..55691 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
CRD75_RS00345 (CRD75_00345)	-	55688..57463 (+)	1776	WP_011284411.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=249808 CRD75_RS00325 WP_002986681.1 52557..53468(+) (comR) [Streptococcus pyogenes strain HarveyGAS]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=249808 CRD75_RS00325 WP_002986681.1 52557..53468(+) (comR) [Streptococcus pyogenes strain HarveyGAS]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462