Detailed information NTG0249063

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: C1A39_RS07725
• Genome accession: NZ_CP028896
• Coordinates: 1494124..1494909 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain CS5
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1489124..1499909

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C1A39_RS07690 (C1A39_07920)	gatC	1489189..1489491 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
C1A39_RS07695 (C1A39_07925)	-	1489631..1489885 (-)	255	WP_024010053.1	glycosyl transferase	-
C1A39_RS07700 (C1A39_07930)	-	1489898..1490095 (-)	198	WP_014608644.1	glycosyltransferase	-
C1A39_RS07705 (C1A39_07935)	-	1490423..1491864 (-)	1442	Protein_1471	6-phospho-beta-glucosidase	-
C1A39_RS07710 (C1A39_07940)	msrA	1492017..1492526 (-)	510	WP_024703984.1	peptide-methionine (S)-S-oxide reductase MsrA	-
C1A39_RS07715 (C1A39_07945)	-	1492538..1493386 (-)	849	WP_024703985.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
C1A39_RS07720 (C1A39_07950)	-	1493510..1494061 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
C1A39_RS07725 (C1A39_07955)	codY	1494124..1494909 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
C1A39_RS07730 (C1A39_07960)	-	1495169..1496383 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
C1A39_RS07735 (C1A39_07965)	-	1496738..1497190 (+)	453	WP_002946987.1	universal stress protein	-
C1A39_RS07740 (C1A39_07970)	-	1497370..1497941 (+)	572	Protein_1478	IS30 family transposase	-
C1A39_RS07745	-	1498013..1498186 (-)	174	WP_011681546.1	hypothetical protein	-
C1A39_RS07750 (C1A39_07975)	-	1498247..1498621 (-)	375	WP_011681547.1	membrane protein	-
C1A39_RS07755 (C1A39_07980)	pflA	1498833..1499633 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=249063 C1A39_RS07725 WP_002951720.1 1494124..1494909(-) (codY) [Streptococcus thermophilus strain CS5]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=249063 C1A39_RS07725 WP_002951720.1 1494124..1494909(-) (codY) [Streptococcus thermophilus strain CS5]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502